UniProt: A0A2D0S1H6

Database: UniProt
Entry: A0A2D0S1H6_ICTPU

LinkDB:  A0A2D0S1H6_ICTPU 
Original site:  A0A2D0S1H6_ICTPU

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Ontology (6)   
   GO (6)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (5)   
   InterPro (3)   
   Pfam (2)   
All databases (16)   

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ID   A0A2D0S1H6_ICTPU        Unreviewed;       383 AA.
AC   A0A2D0S1H6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
GN   Name=ergic3 {ECO:0000313|RefSeq:XP_017336587.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017336587.1};
RN   [1] {ECO:0000313|RefSeq:XP_017336587.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017336587.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000256|RuleBase:RU369013}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC       ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC       apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC       protein {ECO:0000256|RuleBase:RU369013}. Golgi apparatus, cis-Golgi
CC       network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004257}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ERGIC family.
CC       {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR   RefSeq; XP_017336587.1; XM_017481098.3.
DR   AlphaFoldDB; A0A2D0S1H6; -.
DR   Ensembl; ENSIPUT00000006229; ENSIPUP00000005960; ENSIPUG00000004110.
DR   GeneID; 108272605; -.
DR   CTD; 51614; -.
DR   OMA; QRHEGCR; -.
DR   OrthoDB; 506854at2759; -.
DR   Proteomes; UP000221080; Chromosome 12.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR   PANTHER; PTHR10984:SF25; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU369013};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369013};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   TRANSMEM        341..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   DOMAIN          7..97
FT                   /note="Endoplasmic reticulum vesicle transporter N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13850"
FT   DOMAIN          145..363
FT                   /note="Endoplasmic reticulum vesicle transporter C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07970"
SQ   SEQUENCE   383 AA;  42920 MW;  BB31385412845789 CRC64;
     MDALNKLKQF DAYPKTLEDF RIKTCGGATV TIISGLIMLI LFVSELQYYL TKEVHPELFV
     DTSRGDKLKI NIDVVFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGNPVSTEAE
     KHDLGQDEGE IFDPSKLDPD RCESCYGAET DTLKCCNTCD DVREAYRRRG WAFKTPDTIE
     QCKREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSYGLDNI
     NMTHLIKHLS FGKDYPGIVN PLDGTNVAAA QASMMYQYFV KIVPTVYVKG DGEVVKTNQF
     SVTRHEKVAN GLIGDQGLPG VFVLYELSPM MVKFTEKQRS FTHFLTGVCA IIGGVFTVAG
     LIDSLIYHSA RAIQKKIELG KSS
//

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