ID   A0A2D0S5J9_ICTPU        Unreviewed;      1093 AA.
AC   A0A2D0S5J9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Formin-like protein 2 isoform X4 {ECO:0000313|RefSeq:XP_017338034.1};
GN   Name=fmnl2b {ECO:0000313|RefSeq:XP_017338034.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017338034.1};
RN   [1] {ECO:0000313|RefSeq:XP_017338034.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017338034.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin homology family.
CC       {ECO:0000256|ARBA:ARBA00023449}.
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DR   RefSeq; XP_017338034.1; XM_017482545.3.
DR   AlphaFoldDB; A0A2D0S5J9; -.
DR   STRING; 7998.ENSIPUP00000019776; -.
DR   Ensembl; ENSIPUT00000020666; ENSIPUP00000019808; ENSIPUG00000013416.
DR   Ensembl; ENSIPUT00000020719; ENSIPUP00000019857; ENSIPUG00000013416.
DR   GeneID; 108273365; -.
DR   CTD; 492608; -.
DR   OrthoDB; 471257at2759; -.
DR   Proteomes; UP000221080; Chromosome 12.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR043592; FMNL_animal.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR45857:SF1; FORMIN-LIKE PROTEIN 2 ISOFORM X1; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 2.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
FT   DOMAIN          23..468
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          622..1013
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1046..1083
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          677..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1014..1034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..603
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        678..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  124205 MW;  66E22BCF0E8F86C7 CRC64;
     MGNAESVDAQ LTDFRARNKP PKLPMPDPAE LEERFSIALN SMNLPPDKVR LLRQYDNEKK
     WELICDQERF QVKNPPHTYI QKLRGFLDPA VTRKKFRRRV QESTQVLREL EISLRTNHIG
     WVREFLNEEN QGLDVLVEYL SFAQYAVTFD GDAAESASGE ASVETPWSRS IEDLHGDTNL
     PSPVSSSSIQ RSTRHSLRSN TLPSRRTLKN SRLVCKKDDV HVCVMCLRAI MNYQYGFNMV
     MSHPHAVNEI ALSLNNKNPR TKALVLELLA AVCLVRGGHE IILAAFDHFK EVCSESQRFE
     KLMEDFKNED NNIDFMVACM QFINIVVHSV EDMNFRVHLQ YDFTKLALDD YLERLKHTES
     DKLQVQIQAY LDNLFDVGTL LEDAETKNAA LERVEELEES LSHMTDKLLD TENEAMSKIV
     ELEKQLMQKN KELDSLRAVY RDASSQVHSL RRMVREKDEA IQKQSRLEKK IHELERRGSL
     QIQVRGEGDG EGETSPLPSP PQPMPLSPCP DALVQAGAGA SSSYASTSQT GTLRKIATPP
     PPPPPPPPPP PMPDSSLPNG PSAVTAPPPP PPPPPPPPPP PLGRAMEMST QLPPPPPPVA
     PPLPGCGTPT VIFNSGLTAV KIKKPIKTKF RMPVFNWVAL KPNQINGTVF NEIDDERILE
     DLNVDEFEEM FKTKAQGPSV DMTMSKQKAP QKGPSKVSLL EANRAKNLAI TLRKAGKSPE
     EICKAIQSFD LRTVPVDFAE CLMRFMPTEA EVKTLRQYER ERRPLAELTD EDRFMMTFSK
     IERLPQRMTI MAFMGNFSDS LQMLTPQLHA IIAASVSIKS SQKLKKILEI ILALGNYMNS
     SKRGAVYGFK LQSLDLLLET KSTDRKQTLL HYIANVVREK YAAVCMFYNE LHYVEKAAAV
     SLENVLLDVR ELQRGMDLTR REYSMHGHNS LLKDFIHHNE TRLKKLQDDA RISQDAFDEA
     VKYFGESPKT MPPSVFFPVF VRFVKAYRQA DEENEQKKKQ EQLMMEKLLE QEAMMEEQED
     QQSPSHKGKR QQQELIAELR KRQGKDSRHV YEGKDGAIED IITVLKTVPF TARSAKRGSR
     FFCDPTHSED FHY
//