ID A0A2D0S6D1_ICTPU Unreviewed; 532 AA.
AC A0A2D0S6D1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Reduced folate transporter isoform X4 {ECO:0000313|RefSeq:XP_017337780.1};
GN Name=slc19a1 {ECO:0000313|RefSeq:XP_017337780.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017337780.1};
RN [1] {ECO:0000313|RefSeq:XP_017337780.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017337780.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028739}; Multi-
CC pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
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DR RefSeq; XP_017337780.1; XM_017482291.3.
DR AlphaFoldDB; A0A2D0S6D1; -.
DR STRING; 7998.ENSIPUP00000015320; -.
DR GeneID; 108273194; -.
DR KEGG; ipu:108273194; -.
DR CTD; 6573; -.
DR OrthoDB; 51626at2759; -.
DR Proteomes; UP000221080; Chromosome 12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF12; REDUCED FOLATE TRANSPORTER; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 511..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 60149 MW; A4B791BE00A783E7 CRC64;
MADSAVNVKG NGEFEEELIA NSNETEQEFE EPLEHELSPK IDLNTEQQTP RAWKWSVLFL
CFYGFMVQLK PGESFITPYL LSTEKNFTRE QVTNEINPVL SYSYMAVLVP VFLLTDYLRY
KPVLVLQSMS HVSIWLLLLL GTSLLEMQFM EFFYGITMAA RVAYSSYIFS LVPANMYQRV
ASYSRSSVLL GVFTSSVTGQ VCMSLTDITY NTLSAISLGF VSFGLLLSCC LPWPKQSLFF
NQAYRHDERT ATLSELDKIK PDEMVTQGEK ASAGCCSHQL TSSSMNCVFI QMLKEMRNVV
KVPSLRVWSL WWVFSSPGYY LVVFYVHVLW NNLGQAAEQK HVYNGGVEAA STLLGAITSF
VAGFVKIRWK VWSELVIGVI TAAQAGLLLL MCTTSNIWVC YITYIFFRGF YQFLVPIAIF
QIASSLTKEL CALVFGINTF LGTILKSIIT LIVVDKTGLA LPVSSQFFVY FFYFILLTMV
YLGCAAWVIT HHYRNQRQEQ VPSEATTPIE LSPVEKDASE KKPHFNGSTV RT
//
