ID A0A2D0S6Q8_ICTPU Unreviewed; 419 AA.
AC A0A2D0S6Q8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Early growth response protein 2b {ECO:0000313|RefSeq:XP_017338121.1};
GN Name=egr2b {ECO:0000313|RefSeq:XP_017338121.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017338121.1};
RN [1] {ECO:0000313|RefSeq:XP_017338121.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017338121.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU363046}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682, ECO:0000256|RuleBase:RU363046}.
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DR RefSeq; XP_017338121.1; XM_017482632.3.
DR AlphaFoldDB; A0A2D0S6Q8; -.
DR STRING; 7998.ENSIPUP00000010811; -.
DR Ensembl; ENSIPUT00000011268; ENSIPUP00000010811; ENSIPUG00000007377.
DR GeneID; 108273427; -.
DR KEGG; ipu:108273427; -.
DR CTD; 30190; -.
DR OMA; QCQRELH; -.
DR OrthoDB; 2912670at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF54; E3 SUMO-PROTEIN LIGASE EGR2; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363046};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU363046};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU363046};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU363046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU363046};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 307..336
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 337..364
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 365..392
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 287..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 45469 MW; 1ADB7BA0D01D9289 CRC64;
MTAKTLEKSP VTLGGFVHPL SEGIYSLDET TALPASVAIF PNCDLGGHYD QINGISADGL
VGGDMSADKR AVDLPYSSSF AQPAVPRSQT FTYMGKFSID SQYPGNWNPE GVINIVSAGI
LGMTQASSAS SSPSSSSSVS PAHFSSTLSC TVAQGQTDME QQHIYSPPPP YSGCAEVYQD
PSAFLSTSTC PISSYPPPAY SSPKPSADAG LFPILPDYSG FFQPPCQRDM QSIPERKPFA
CPLEPFRVPP PLTPLNTIRN FTLAAPVAEG ARLPAAYSPQ NLPLRPILRP RKYPNRPSKT
PVHERPYPCP AEGCDRRFSR SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT
GEKPFACDYC GRKFARSDER KRHTKIHLRQ KDRKATASSS SSSSSVPAGG SNSTSGISQ
//
