ID A0A2D0S7L7_ICTPU Unreviewed; 884 AA.
AC A0A2D0S7L7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=C-terminal binding protein 2, like isoform X1 {ECO:0000313|RefSeq:XP_017338426.1};
GN Name=ctbp2l {ECO:0000313|RefSeq:XP_017338426.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017338426.1};
RN [1] {ECO:0000313|RefSeq:XP_017338426.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017338426.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017338426.1; XM_017482937.3.
DR AlphaFoldDB; A0A2D0S7L7; -.
DR GeneID; 108273599; -.
DR KEGG; ipu:108273599; -.
DR CTD; 548605; -.
DR OrthoDB; 4204864at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd05299; CtBP_dh; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR043322; CtBP.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR46029; C-TERMINAL-BINDING PROTEIN; 1.
DR PANTHER; PTHR46029:SF3; C-TERMINAL-BINDING PROTEIN 2; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 519..833
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 615..798
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT REGION 64..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 96040 MW; 5F4CA0008A272344 CRC64;
MKIDPIADSS NHLKAMAVRG TVPPPDYYPF DTALSAQPPE DLQGFYRGSH QLLSRSGSHY
GLGAGGVRSA WDQGQARAPT RAPTPGPAPP PPPPPPPPPP PPPPTAHELS RMYRDSLAFP
DSQRIRSRAA SPACFGIAAD QASLAGHSGY NEVNGLHFDH PPSTCIMMDP APNSIVDGSV
HRGMSAYGTL PAQRLAYDPA YDAATPAQLT TGITTHHPST AVNMDPKRAV DPAFLTYLRT
EGLSESTISL LLQQGFDSTS MLSMMEEHDV RSMTPNLGQA RVLSRVVLNC KTGGTGAPAM
RGRSNSFSHR NDLYAQPQGL AMDSHFLQQP SNTLQTVSPR IGEFINRRPS SAPSQHLLET
TSYPGMRSLG GFQANTGAQT QPLAMYNPHT GLPMSSHPQP QQPAIFNTSG LVNKAFSNPY
TPIELMKRAP SLPQMPQTPG AHPSPQLLRK GATMENTVVS TGTTMQSQAH NQNNKMTRRT
GPPIIVSTMA STDTSIRPQI MNGPMHPRPL VALLDGRDCT VEMPILKDLA TVAFCDAQST
QEIHEKVLNE AVGAMMYHTI TLTREDLEKF KALRIIIRIG SGYDNIDIKA AGELGIAVCN
IPSAAVEETA DSTICHILNL YRRNTWLYQA LREGTRVQSV EQIREVASGA ARIRGETLGL
IGFGRSGQAV AVRAKVFGFS VIFYDPYLQD GLERSLGVQR VYTLQDLLYQ SDCVSLHCNL
NEHNHHLIND FTIKQMRQGA FLVNTARGGL VDERALAHAL KEGRIRGAAL DVHENEPFSF
AQGPLKDAPN LICTPHTAWY SEQASLEMRE AAATEIRRAI TGRIPDSLRN CVNKEFFITT
SAWGVMEQQT GHPELNGAAY RLNTQVTQSL QAITAGAPQD KINA
//
