ID A0A2D0S7Z6_ICTPU Unreviewed; 1480 AA.
AC A0A2D0S7Z6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Rho GTPase-activating protein 23 isoform X3 {ECO:0000313|RefSeq:XP_017338869.1};
GN Name=arhgap23b {ECO:0000313|RefSeq:XP_017338869.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017338869.1};
RN [1] {ECO:0000313|RefSeq:XP_017338869.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017338869.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017338869.1; XM_017483380.3.
DR STRING; 7998.ENSIPUP00000006379; -.
DR Ensembl; ENSIPUT00000006665; ENSIPUP00000006379; ENSIPUG00000004340.
DR GeneID; 108273815; -.
DR KEGG; ipu:108273815; -.
DR CTD; 562244; -.
DR OMA; SAWATMV; -.
DR OrthoDB; 2997116at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 48..157
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 734..858
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 950..1141
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 488..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1480 AA; 163393 MW; 78BF11D87EAA5180 CRC64;
MNGVAFCLVG IPPVSQSEAK GPRDGALLSN ENARPVSREG VAWKGPRTVV LQKNSQGFGF
TLRHFIVYPP ESALHTSVKD VENGNGKGNH KGRLEPMDTI FVKSVKEMGP AHQAGLCTGD
RLVKVNGESI LGKTYSQVIA LIQNSKSVLE LSIMPKDEDV LQLVSAYSQD AYLKGNLPYS
GGAQNLPEPP PIFYPRSKPT SSGMPGNLNC RRGSAGLIDS RSMGDSTGGT GQRLDVPSRH
TLRNQRARSS TIAISPLDFH FANHSAAITS ASLPYQRKGS LPLSQSELCH QALAKWYHSQ
TERPGMSHHH RSISQDTLLC HYGTAMGVNQ SPYIDSCWMG RWGMTGAHQS NLSCSENLLP
AYAEYDSHGR SLEKLDKAVA LVSPRFEKLA CAPQSGQPVR KEEQPCLTNQ HAVICADVPP
LGRGFSHAQD QTGSHSYHSA QPRCLPTQTV DDQMVGYRSY SPSFCRKAGH LMQQAHSFKD
SSYTGPHLSW TTPKTSPPDS APSSGRDSSP LSMSSTAETQ NSAKESSDSG PTVEEPVHAQ
MQEVVLRQKP PYAKCTPHAM RHPNYAVPVD LLEPPVASAP ARSNGNLQTL PVEQDSLASI
PFIDEPTSPS VDLLAQHVPA SSVVSSSLCQ APILSSSPVP PPLTSPLTHL LDTDCSTVKN
SRRSSYLLAI TTERSKSCDE GLNTFRDEGR VFMRLPKRVK SFFTEGSLES LRVAEEARSK
RHSTSELGNI TLTDIRKEGW LHYKQILTEK GKKVGGGMRP WKRVFSVLRS HSLFMYKDKR
EAVLHGAGSL GHGGGGGGGG EDEQPISIRG CLIDIAYSET KRKHTLRLTT QDFCEYLLQA
EDRDDMLSWI RIIRENSKTD NEELGFSRQA LISKKLNDYR KQSLTGTKPD TSPRVHRMMQ
PFLLSKTDSS SGVNRSLKTE SKEESSPPKA TWSINIMKKG KKAGPKAFGV RLEDCPPGAN
NKFVPLIVET CCNLVEEMGL EYTGIYRVPG NNAMVSTLQD QLNKGMEINT AEERWQDLNV
ISSLLKSFFR KLPEPLFTDD KYNDFIYANR LEDAGDRLKT MRKLIRDLPD HCYHTLKFLI
SHLKRVADHS AKNKMEPRNL ALVFGPTLVR TSEDNMTDMV THMPDRYKIV ETLILHHAWF
FTDELMDKDE KTPEDQRDEQ PIPNIDHLLS NIGRTAPLGD ASDSTNSDSA KSKGSTISKK
DVSAKDFLPL SIISAVTRKR KKHRSACPTD SSSDEDSEHE PVKASNYGEL SENVGNETDG
GHEESKIGCA AQSTGSQTTE VDEKDVEGKR MMEAHEGGEQ EVEGRESTGS QQEDDGIRVD
VSVRAQLGQE QPQRPRSFLY SHQNSPAQSV TDQSTSSPSS PCTSDAHRLS QVNSASRKKL
RGERARPRSL YEEPGLERAV GLARVKASLV RGQERLRQAM SPSRDPSVQP SWLSQVHANF
LSSANDLWRS GTQRRHASPE TRRRRRDWRR HTVVGNSGES
//
