ID A0A2D0S8V6_ICTPU Unreviewed; 1207 AA.
AC A0A2D0S8V6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protein transport protein Sec24C isoform X4 {ECO:0000313|RefSeq:XP_017339179.1};
GN Name=sec24c {ECO:0000313|RefSeq:XP_017339179.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017339179.1};
RN [1] {ECO:0000313|RefSeq:XP_017339179.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017339179.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_017339179.1; XM_017483690.3.
DR AlphaFoldDB; A0A2D0S8V6; -.
DR GeneID; 108273969; -.
DR CTD; 9632; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF5; PROTEIN TRANSPORT PROTEIN SEC24C; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 535..573
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 612..855
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 861..944
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 957..1056
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1077..1149
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..188
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..332
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 130480 MW; 993B6EAFE8C3553A CRC64;
MNVNQQPHMA SPYGQPQSGY QGNPHSGYGG QQLPGGYVGP YAPYNGPASN YQTGPPQGMR
GPPTSGAPPV SAAQPYSQFG QSEVQNGPPS MGAPPQRPSA SQPYTQGSVS LSGPQPAYPQ
QFGAPPTTMQ QVTNQMAGMQ VGSTIPSSAG PGYALPAISQ APVPAPPSSF VPTAPVPTRP
PPTSGPPHTP AQSYYGAPPA HQPFPATAPP FSSAPGPTQL PPPPLASQQT FSQASPLSQP
QFSSAPPTGP AALYGGPPPS VQATHSRAPL PTSQPSAFSG GPPPSSAPSQ YSTTMPPASQ
PSPFHSGPPP PTTAPGFPPQ AGAPPRPPHS GMQGPPMASQ GPPMASQGLP MASQGPPMSQ
VNHVTPPQPG MLHGPTTPGM APPQPGMQGY PPQQNGAFGQ VRAPQPGYGG PYSGQQGYGA
QPSAQAPPPA AKRLDPDSIP SPIQVIEDDK ANKSNEPFVT GVRGQAPPLV TTNFHVKDQG
NASPRFIRCT AYNMPCTSDM AKQSQVPLAA VIKPLATLPP DENPPYIVDH GESGPIRCNR
CKAYMCPYMQ FIEGGRRFQC SFCNCVTEVP PHYFQHLDHT GKRVDCYDRP ELSLGSYEFV
ATVDYCKNNK IPQPPAFIFL IDVSYNAVKS GMVRIVCQEL KSLLDYLPRE NPDMDSNIRV
GFVTYNKVLH FYNVKASLAQ PQMMVVSDVA DMFVPLLDGF LVNVSESRVV IESLLDQIPE
MFADTRETET VFGPVIQAGL EALKAADCVG KLFVFHTSLP IAEAPGKLKN REDKKLVGTD
KEKTLFQPQV SFYANLVKDC VAQGCCVDLF LFPNQYVDVA TLGVVPTSTG GSIYKYTYFQ
AQSDQERFLN DLRNDVQKQV GFDAVMRVRT STGIRATDFL GSFYMSNTTD VELACLDCDK
TITVEFKHDD KLSEETGALI QCAVLYTSCG GQRRLRIHNM AVNCCAQLAD LYRNCETDTI
INFFAKYAYR SVLNNPTKNV RDSLVNQCAQ ILACYRKNCA SPSSAGQLIL PECMKLLPVY
LNCVLKSDVL HPGADVSLDD RAYLRQLVSA MDVAESHVFF YPRLLPVHKL DVESDALPVA
VRDSEERLSK GGIYLLETGL NLFLWVGVNT QQELLQNIFG TPAFSQIDPN MTSLPMLDNP
YSKRLREIIE SFRTQRSRYM KLVVVKQEDK LELIFKHFLV EDKNNSGGAS YVDFLCHMHK
EIRTLLS
//
