ID A0A2D0S9S0_ICTPU Unreviewed; 628 AA.
AC A0A2D0S9S0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transcription factor 7-like 2 isoform X5 {ECO:0000313|RefSeq:XP_017339482.1};
GN Name=tcf7l2 {ECO:0000313|RefSeq:XP_017339482.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017339482.1};
RN [1] {ECO:0000313|RefSeq:XP_017339482.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017339482.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017339482.1; XM_017483993.3.
DR AlphaFoldDB; A0A2D0S9S0; -.
DR GeneID; 108274114; -.
DR CTD; 6934; -.
DR OrthoDB; 5351131at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01366; c-clamp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 346..414
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 346..414
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 69052 MW; F53DB30314DDFC2F CRC64;
MPQLNGGGGD DLGANDEMIS FKDEGEQEEK ISENSSAERD LADVKSSLVN ESETNQNSSS
DSELTVLPLC CVQRSAVSLH LKAERRPPPR AETFRDKTRE SLEEAAKRQD GGLFKSPPYP
GYPFIMIPDL TSPYLSNGSL SPTARTYLQM KWPLLDVQAG SLQSRQALKD ARSPSPAHIV
SNKVPVVQHP HHVHPLTPLI TYSNEHFTPG NPPPHLQTDV DPKTGIPRPP HPSDISPYYP
LSPGTVGQIP HPLGWLVPQQ GQPVYPITTG GFRHPYPTAL TVNASMSRFP PHMVPPHHSL
HTTGIPHPAI VTPNVKQESS HSDISTLNSS KHQDQKKEDE KKKPHIKKPL NAFMLYMKEM
RAKVVAECTL KESAAINQIL GRRWHALSRE EQAKYYELAR KERQLHMQLY PGWSARDNYA
ANQQGKKKKR KREKQQADGN EHREYFPNPC LSLPPITDLS APKKCRARFG LDQQNNWCGP
CRRKKKCIRY IQGEGSCVSP PSSDGSLLES PPSSPSMVPN SPPSKESKPQ TEQMQPLSLT
MKSGPLVSSS HHQHHHLSMA PPPPLALLDN SGAGKTHGPA HNGSLDPSDV SSSRPSGSAQ
PASACNSHSL LPSSAPTQPL SLVTKSID
//
