ID A0A2D0SAK7_ICTPU Unreviewed; 381 AA.
AC A0A2D0SAK7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protein shisa-9A {ECO:0000313|RefSeq:XP_017339768.1};
GN Name=shisa9a {ECO:0000313|RefSeq:XP_017339768.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017339768.1};
RN [1] {ECO:0000313|RefSeq:XP_017339768.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017339768.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
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DR RefSeq; XP_017339768.1; XM_017484279.3.
DR AlphaFoldDB; A0A2D0SAK7; -.
DR STRING; 7998.ENSIPUP00000002423; -.
DR Ensembl; ENSIPUT00000002557; ENSIPUP00000002423; ENSIPUG00000001767.
DR GeneID; 108274240; -.
DR KEGG; ipu:108274240; -.
DR CTD; 541382; -.
DR OMA; MTHNLMT; -.
DR OrthoDB; 5350575at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..381
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012994294"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 381 AA; 42876 MW; CEAA29CBF7D55832 CRC64;
MRWTVLLWEY LLVEVTALVC RADGEAERRL EGFVVLSGSN GSEESGVSEK PHTQDECRGY
YDVMGQWDPP FVCRTGTYLY CCGTCGFRFC CAYKSSRLDQ SLCTNYNTPV WLKGQTPHKK
TDPRHDPTKD KTNLIVYVVC GVVAIMALVG IFTKLGLEKA QRPHRENMTR AVASVMQGAC
QAEHEEAIGR HAQNYDNMQA RANNMQGAQM HSMNQAHPYP VLSQLAHVYE QQQPGKELNK
YASLKAVASN VNGGFYNKQH CHLTELGAKG SLPLHTMRME HVEPTATYVT EIPIPKQNEQ
KPKPTKPHVP HHHMAYSSNT IANPGMLKAW DGTETVGRRK TYGPRKPCMV GQMNELHTAR
SHHYLPTQPY FITNSKTEVT V
//
