ID A0A2D0SCW5_ICTPU Unreviewed; 848 AA.
AC A0A2D0SCW5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 {ECO:0000313|RefSeq:XP_017340311.1};
GN Name=LOC108274607 {ECO:0000313|RefSeq:XP_017340311.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017340311.1};
RN [1] {ECO:0000313|RefSeq:XP_017340311.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017340311.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00010594}.
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DR RefSeq; XP_017340311.1; XM_017484822.3.
DR AlphaFoldDB; A0A2D0SCW5; -.
DR STRING; 7998.ENSIPUP00000011479; -.
DR Ensembl; ENSIPUT00000011966; ENSIPUP00000011479; ENSIPUG00000007773.
DR GeneID; 108274607; -.
DR KEGG; ipu:108274607; -.
DR CTD; 101886447; -.
DR OrthoDB; 1366859at2759; -.
DR Proteomes; UP000221080; Chromosome 14.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF127; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2-LIKE; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..848
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012158006"
FT DOMAIN 49..92
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 93..136
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 848 AA; 95607 MW; 263F6F251E0FF8F3 CRC64;
MLHGKLVVCV FLLVLGPRVC VGYVFQAAQP TEEKEEIPVH PKISIWESTA GSCKGRCFEL
VEAEPPGCRC DNLCKTYYSC CADFDKQCLK TAGGFECTAE RCGESRNEDY ACQCSEDCLE
KGDCCTNYNA LCKGGSQWLD GDCEEINTPV CPAGFVRPPL FIISLDGFRA SYIKKGKSVI
PNIHKLRTCG TRSPHMRPVY PSKTFPNLYT LATGLYPESH GIVCNSMYDP VFDANFNLRG
REKLNPRWWG GQPIWITAEK QGVKAATFFW PWVIPLERRI LTMLSWLHLP DDERPYVYAV
HSEQPDAFGH RLGPLSNELD NPLREIDNII GQLMNGLKQM NLHRCVNVII VGDHGMEEAH
CDRTEYLSSY GLNVNEFTLI PGSSGRLRPK NQSVPYDPKE LAANLTCKMP NQHFKTYLKQ
HLPKRLHYAN NRRIEDVHLL MERKWLVAMN RLPGSCGYFG DHGFDNKISS MQTIFLGYGP
SFKFRTEVPP FENIELYNVM CDLLGLTPAP NNGTRGSLNS VLKDPPYKPI QPEEVTSPAP
LEPAETSLPY NLGCSCDDEN MIEESTDGLL AEGAASLNNV THLPFGRPAV LFQTSYSLLQ
HSDYVGAYSY ELRMPLWTAF TITPQIESTA SPLPGSECVR ADVRIPPKHT PTCDSNNQEN
KIIRGFLYPP GLSITPESRY DASLITNTVP IYPAFKRIWN YLQMTVLKRY SEERNSINVV
TGPIFDYDFD GLRDTVEKIK EHAGDSAPVP THFYVIITSC EEENTTVEEC DGAISPVSFI
LHHRPDNSES CNSSDEPSRW VEEILRTHTA RVRDVELLTG LDFYRSVALP YTNTLTLKTY
LHTFEENV
//
