ID   A0A2D0SEN6_ICTPU        Unreviewed;       432 AA.
AC   A0A2D0SEN6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Major histocompatibility complex class I-related gene protein {ECO:0000313|RefSeq:XP_017340705.1};
GN   Name=LOC108274817 {ECO:0000313|RefSeq:XP_017340705.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017340705.1};
RN   [1] {ECO:0000313|RefSeq:XP_017340705.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017340705.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   RefSeq; XP_017340705.1; XM_017485216.3.
DR   AlphaFoldDB; A0A2D0SEN6; -.
DR   STRING; 7998.ENSIPUP00000006118; -.
DR   GeneID; 108274817; -.
DR   KEGG; ipu:108274817; -.
DR   OrthoDB; 3840485at2759; -.
DR   Proteomes; UP000221080; Chromosome 14.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd12087; TM_EGFR-like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF193; LOC571647 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        329..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          219..308
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          383..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  47934 MW;  FF5EF245507CDBAE CRC64;
     MRMKMMKMMK VMTVVSVFVA LGALAPALGG QHSLYYTYTA LSNPMKLPGI YEFTALGMLD
     DRELDYYTSE TQSKVPKQHW MREKMPQDYW EKGTQSRKSK EQWFKVNVDI LMERMGHNKT
     ELHVLQWRHG CEVETTGGKI KFVSGVDEYS YDGTEFLSFD EENSRWIAPV PAAEPTKRKW
     DEVPILNQYT KGYLEKECVD WLEKFMDYGK EELRKHSPPD VHLFAKKSVT DPSKLTLTCL
     ATGFYPPDIE MRLRKLRTSL PEHLVTSSGV RPNGDGSYQL RKSVDIVEDD KALYDCYVNH
     ETLREPIIIP DGKGIPCPDC TAPSTQSCII GGVVGVLLTL AVVAGIIFFL RRKGIISSGC
     NDGSPANSTV HVPLAAPATV SAAVSATQGH SDTGSDSKGA KDSDSTRDSG KGSGSGSSDS
     SQENIDETSK MI
//