ID A0A2D0SEN9_ICTPU Unreviewed; 957 AA.
AC A0A2D0SEN9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Protocadherin alpha-2 isoform X4 {ECO:0000313|RefSeq:XP_017341193.2};
GN Name=LOC108275110 {ECO:0000313|RefSeq:XP_017341193.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017341193.2};
RN [1] {ECO:0000313|RefSeq:XP_017341193.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017341193.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_017341193.2; XM_017485704.3.
DR AlphaFoldDB; A0A2D0SEN9; -.
DR Ensembl; ENSIPUT00000012884; ENSIPUP00000012362; ENSIPUG00000008407.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000221080; Chromosome 14.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF32; CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 10-RELATED; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 704..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 147..255
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 256..363
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 364..468
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 469..577
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 584..695
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 912..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..946
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 104425 MW; 3BB4BBBE5A4D543D CRC64;
MFGECLDVFP ESAYTAMGRP MQKAIVCIRV IALLCSLAVC AAQISYSVSE EVDKGTFVGN
IAKDLNINGQ ELERRGLRVV SGHNKRYFDV NLKTGVLFVN ERLDREELCG DSDKCVINIE
AMMNNPVHLN RIEINILDAN DNAPFFLEES YFVNTSELAV IGEKFPLPVA NDADSRSNSV
KNYKLSPNEH FSLEVQSGGE HSVSAELVLQ KALDREKQPV ILLSLTAIDG GKPAKSGALR
IIVNIEDAND NIPAFSKPLY KVRVAENTPV GTTIIKLVAT DLDEGVNGEL VYSLSAGGSS
KIFDKFAINS ITGEITTKEK LDREENSAHE IRAQARDRGS PSRGTHCKVL VEVLDINDNA
PEISVSSMMN SVKEDSALGT VIASVTVTDK DSEQNGDIKV HVIGHLPFNL KQSYKNYYSL
ILDSSLDRES VSEYDVTIKA TDEGTPPLSS ITVITVHVSD VNDNAPRFPE SVINVYVKEN
SQVGSVIYIA SAFDPDVGDN GRISYSLLES SKSILASSMI NINSDSGDIH SLQSFNHEEM
KTFQFKVQAT DSGVPPLSSN VTVNVFILDE NDNNPGILAP YSDHGSVHSE NIPYSVEAGY
FVTKIRAVDS DSGYNALLSY HISEPKGNNL FRIGTSSGEI RTKRRMSDND LKTHPLVILV
SDNGEPSLSA TVSIDVVVVE STGDIKSQFK HAPIKEDSFS DLNMYLLIAI VSVSVIFLLS
LISLIAVKCC RTDSSFSRYS APVITTHPDG SWSYSKSTQQ YDVCFSSDTL KSDVVVFPAP
FPPADADLIS INEGETFNRT QTLPNKEKPK APNADWRYSA SLRAGMQSSV HMEESSVMQG
AQGVLVQNWP TVSNAPDNEG GEVSPPVGAG VDSNSWHFRY GPGPGMPPQH LKPGEVPPEA
FIIPGSPAII SIRQGQDGDD KSDFITFGKK EEAKKKKKKK KEKEKKDKKE KGKDDDD
//
