ID A0A2D0SIU7_ICTPU Unreviewed; 170 AA.
AC A0A2D0SIU7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
GN Name=cav4b {ECO:0000313|RefSeq:XP_017342622.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017342622.1};
RN [1] {ECO:0000313|RefSeq:XP_017342622.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017342622.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC Interacts directly with G-protein alpha subunits and can functionally
CC regulate their activity. {ECO:0000256|RuleBase:RU000680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane
CC protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola
CC {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU000680}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the caveolin family.
CC {ECO:0000256|ARBA:ARBA00010988, ECO:0000256|RuleBase:RU000680}.
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DR RefSeq; XP_017342622.1; XM_017487133.3.
DR AlphaFoldDB; A0A2D0SIU7; -.
DR STRING; 7998.ENSIPUP00000019611; -.
DR Ensembl; ENSIPUT00000020462; ENSIPUP00000019611; ENSIPUG00000013317.
DR GeneID; 108275955; -.
DR KEGG; ipu:108275955; -.
DR CTD; 791212; -.
DR OMA; RIWTYRC; -.
DR OrthoDB; 5357157at2759; -.
DR Proteomes; UP000221080; Chromosome 15.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR InterPro; IPR001612; Caveolin.
DR PANTHER; PTHR10844; CAVEOLIN; 1.
DR PANTHER; PTHR10844:SF13; CAVEOLIN; 1.
DR Pfam; PF01146; Caveolin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU000680};
KW Golgi apparatus {ECO:0000256|RuleBase:RU000680};
KW Membrane {ECO:0000256|RuleBase:RU000680, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 16..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 170 AA; 19128 MW; 3235E69F88D06245 CRC64;
MMSDDYLVDC KIDDDDYDEE EMKIQPTPTP PSEFCSSSQV SKSYGETRDP YGANNHLRME
LSDVLAEPAS SHSYERVWVY SSIGFESARI WSYRCLTALF AVPISCLSGC LFALLACLHI
WCVMPCVQVC HTCLPCVRSL WMSVVNIFIM PLCMSAAHCC SGIYVLFSNE
//
