ID   A0A2D0SKT1_ICTPU        Unreviewed;       967 AA.
AC   A0A2D0SKT1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Rho GTPase-activating protein 4a isoform X1 {ECO:0000313|RefSeq:XP_017343096.1};
GN   Name=arhgap4a {ECO:0000313|RefSeq:XP_017343096.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017343096.1};
RN   [1] {ECO:0000313|RefSeq:XP_017343096.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017343096.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017343096.1; XM_017487607.3.
DR   AlphaFoldDB; A0A2D0SKT1; -.
DR   GeneID; 108276165; -.
DR   KEGG; ipu:108276165; -.
DR   CTD; 393416; -.
DR   OrthoDB; 2904755at2759; -.
DR   Proteomes; UP000221080; Chromosome 15.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd07656; F-BAR_srGAP; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR   PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW   ProRule:PRU01077};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          83..349
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          531..716
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          758..817
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          442..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          821..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          923..967
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        923..951
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   967 AA;  109971 MW;  91C6367B12E4B57F CRC64;
     MRCIQGVALN ERSRIELAVI FRVIIYTDSV DHFHCKPVSE CLLDGSAGWN WMESKFHVVG
     ATMSSYNVKL RRAGIADYDT QIKEVRNQLS EQLRVFDNHL EQKTQVLQDL SDYLRRRGEI
     EGEYARSLDK LADRFASKTK KKESSSESVL KCWQELLTQT RHESKDHITL SENCGTTLPQ
     QLSRCLELVQ RLAKKNKEIS TQLQDGLLKV TVELQTTLKT YSQYHTEYLS AEGKLKEATK
     QEEKQKLSAA KKMERLIEKR QCKVQETQLK CTKARNDYLF NLEATNASMN KYYLQDLSAL
     IDFSDLGFHQ SLSQVLQFYL SRRLQAHQNL GSGLQQLGNA LSGLDQNQDR DTLIQAHDTA
     FCMPLRFQYQ PHEGDQVCEV NADFEVKSEL DTRFHQLKTR LNTVTAENEE LSKMLQLSHS
     ALIEYITEDV FRPEHSQSLE NISEASNNKI NQARRRSNLQ ETENSYSTKF KDHLINGLLI
     SKLQAKHDLL QVAIQKAGTV DGRHHRMRSR RSVRQRKNQH DSQICQKAFS RDLLAYIQAS
     GEPIPLVVES CIRFINLHGL HHEGIFRVPG SQLEVNRLRD LFEKGDDPLA EEICDLDSVA
     CVLKLYFRGM ENPLFPKDSY DLLMECGRIE DESEKVAQLK AVILSYPSPV VVVMRYLFAF
     LHHISQYSDE NMMQPYNLAV CFGPSLIRGP EDADAVTLQH INALVKTIII QHESIFPNQN
     ELDGPVYETC MTLEPDDTEA TTEESEVEPD MSPNKEVKDE LEGVALFDYT ARSSTELSFK
     QGGRLRLYSR ASSEWWRGEI DGSKGLIPNK YISVLSMEGG PEHKEIRNSG SQGEDQATGP
     TQTRIKVFSD KSGLGSSQAI AGKISLQLPT AQLLSTSPRA LRKTDTQIRR TAADSEREDA
     KISVDKEVCQ QMNSVFKELL VRQQQQEHVS PSSVPPSYSS GSTQTLNKRG MTPQKGKGYF
     KSSEQMN
//