ID A0A2D0SLI0_ICTPU Unreviewed; 389 AA.
AC A0A2D0SLI0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Partitioning defective 6 homolog beta {ECO:0000313|RefSeq:XP_017343356.1};
GN Name=pard6b {ECO:0000313|RefSeq:XP_017343356.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017343356.1};
RN [1] {ECO:0000313|RefSeq:XP_017343356.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017343356.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PAR6 family.
CC {ECO:0000256|ARBA:ARBA00008625}.
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DR RefSeq; XP_017343356.1; XM_017487867.3.
DR AlphaFoldDB; A0A2D0SLI0; -.
DR STRING; 7998.ENSIPUP00000020195; -.
DR Ensembl; ENSIPUT00000021066; ENSIPUP00000020195; ENSIPUG00000013710.
DR GeneID; 108276298; -.
DR KEGG; ipu:108276298; -.
DR CTD; 84612; -.
DR OMA; HEPTQNG; -.
DR OrthoDB; 5401122at2759; -.
DR Proteomes; UP000221080; Chromosome 15.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd06403; PB1_Par6; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034868; PB1_Par6.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14102; PAR-6-RELATED; 1.
DR PANTHER; PTHR14102:SF4; PARTITIONING DEFECTIVE 6 HOMOLOG BETA; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 15..95
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 157..250
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 254..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 42656 MW; 7368AAE3F37984F3 CRC64;
MNKNHRVPSS RSLSAVEVKS KFGAEFRRFS LDRSKPGRFD EFYGLLQHVH RIPNVELLVG
YADIHGDLLP INNDDNYHKA ITTATPLLRL FLQRKEEADY STFGTNSLTR KKPPLAAVLL
RPDAGRKKPA VVISLPRDFR PVSSIIDVDV LPETHRRVRL YKHGQEKPLG FYIRDGSSVR
VTPHGLEKAP GIFISRMVPG GLAESTGLLA VNDEVLEVNG IEVAGKSLDQ VTDMMIANSY
NLIITVKPAN QRNNVVRHNN NSGGAASGSS GRSSDSGASY YSYTTPVAMV TAPAQIIQNF
HPEEVDSDED DEDLVIEAAQ DSRLAPGPGT EASSSMSTLP RYKPHLDLRH SNGTFQHPVM
SSTSAESPRG PERGVQTQNL EEDGTVITL
//
