ID A0A2D0SMH4_ICTPU Unreviewed; 941 AA.
AC A0A2D0SMH4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Short transient receptor potential channel 4a {ECO:0000313|RefSeq:XP_017343908.1};
GN Name=trpc4a {ECO:0000313|RefSeq:XP_017343908.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017343908.1};
RN [1] {ECO:0000313|RefSeq:XP_017343908.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017343908.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017343908.1; XM_017488419.3.
DR AlphaFoldDB; A0A2D0SMH4; -.
DR STRING; 7998.ENSIPUP00000016531; -.
DR GeneID; 108276614; -.
DR KEGG; ipu:108276614; -.
DR CTD; 102725537; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000221080; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF25; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_017343908.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 141..173
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 176..238
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 865..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 107880 MW; 13CE3370712CC71F CRC64;
MSQLYYRRTG NSSYRDRIPL RIVRAESELS PLEKAYLNAV EKGDYASVKQ ALEEAEIYFK
ININCIDPLG RTALLIGIEN ENLEIIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK
PSGGMQVPPI LLDKQFSDFT PDITPIILAA HTNNYEIIKL LVQKGVSVPQ PHEVRCNCVE
CVSGSDVDSL RHSRSRLNIY RALSSPSLIA LSSEDPFLTA FLLSWELQEL SKVENEFKAE
YEELSHQCKQ FAKDLLDQTR SSRELEIILN YRDDINPLED EGNNNDLARL KLAIKYHQKE
FVAQPNCQQL LASRWYDEFP GWRRRHWAGK FVTCIFIGLL FPLFSIFYLI APKSHYGLFI
RKPFIKFICH TASYLTFLFL LLLASQHVVT TDSGRQGPAP TTVEWMILPW VLGFIWAEIK
QMWDGGFQDY VHDWWNLMDF VMNALYLATI SLKIVAYTKY SDVKPRNDWE MWHPTLVAEA
LFAIANIFSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
YYETEASNKT GNCKGIRCVQ QNNAFSTLFE TLQSLFWSIF GLISLYVTNV DPEHQFTEFV
GATMFGTYNI ISLVVLLNML IAMMNNSYQH IADHADIEWK FARTKLWMSY FEEGGTLPPP
FNIIPSPKSA WYLIMWIKKH ICKRTRSERT ATFGSISRRA ARNVHINHQY QEVLRNLVKR
YVAAMIRDAK TEEGLTEENF KELKQDISSF RYEVLGMMKG NKPSKGSTGA SNMAYCEHPM
KCSTAPTGES LKSKLKLFNV TTSILQQNSK ANTKNTEHYL ANGSIRTPSE TTSSNRTSDF
SGLYHQIWHR GTNDPGRIYS VCEEVGESDT EELGEKTKND KPSESLIMKK ANENEMGESS
NETKEVHKMI EERNRFSDIP CICDNDVNDE STENYEEISR L
//
