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Database: UniProt
Entry: A0A2D0SNI3_ICTPU
LinkDB: A0A2D0SNI3_ICTPU
Original site: A0A2D0SNI3_ICTPU 
ID   A0A2D0SNI3_ICTPU        Unreviewed;      5073 AA.
AC   A0A2D0SNI3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 4.
DE   SubName: Full=ryanodine receptor 1-like isoform X3 {ECO:0000313|RefSeq:XP_017344264.1};
GN   Name=LOC108276801 {ECO:0000313|RefSeq:XP_017344264.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017344264.1};
RN   [1] {ECO:0000313|RefSeq:XP_017344264.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017344264.1; XM_017488775.1.
DR   UniGene; Ipu.78417; -.
DR   GeneID; 108276801; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017344264.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4366   4384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4591   4611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4677   4698       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4813   4831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4875   4895       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4954   4977       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      592    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1348   1562       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      465    485       {ECO:0000256|SAM:Coils}.
FT   COILED     1888   1919       {ECO:0000256|SAM:Coils}.
FT   COILED     2101   2121       {ECO:0000256|SAM:Coils}.
FT   COILED     3696   3723       {ECO:0000256|SAM:Coils}.
FT   COILED     4288   4308       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5073 AA;  575611 MW;  AFD2F647F70BB07D CRC64;
     MAEGGEGDEE IQFVRTEDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICVFILE QSLSVRALQE MLSHTSEDVD LDKWSSQGGG HRTLLYGHAI LLRHTHSGMY
     LSCLTTSRSL TDKLAFDVGL QEDSTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE
     RYLHLSYASG DLMVDASFMQ TLWNMNPVSS GCELVEGYLT GGYVLRLFHG HMDECLAIPA
     AEQGEERKNA HYEGGPVCSH ARSLWRLEPL RIGWSGGHIK WGQPFRVRHI TTGRYLCLDD
     EKGLLVVDPE KANTKSSAFC FRASKEKTEV AQKRDVEGMG APEIKYGESM CFVQHVATGL
     WLTYASVDAK SARLGPVKRK AILHQEGHMD DALTVARSQT EESQAARMIY STAGLFTQFI
     KSLDTLSGKN KSAAPPPPSL PLESVVLLLQ DLIFYFRPPD EDLEHEEKQS KLRSLKNRQN
     LFQEEGMITL VLDCIDRLNV YNTSAHFSEF AGEEAAESWK EIVNLLYELL ASLIRGNRAN
     CALFCDNLDW LVSKLDRLEA SSGILEVLYC ILIESPEVLN IIQENHIKSI IALLDKHGRN
     HKVLDVLCSL CVCNGVAVRS NQNLITENLL PRRDLLLQTQ IINYVTSMRP NIFLGTCEGS
     TQYKKWYYEL IVDHVEPFLT AQAGHLRVGW ALTEGYSPYP GGGEGWGGNG VGDDLYSYSF
     DGLHLWSGRV PRHVASPSQH ILAAEDVVSC CLDLSVPSIS FRINGHPVQG MFENFNLDGL
     FFPVVSFSAG IKVRFLLGGR HGDFKFVPPP GYAPCYEAVL PKDKLRIEPI KEYKNDLDND
     VRNLLGPTQS LSHTAFTPNP VDTVQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTYGP
     FRDDNKKLHP CLLDFQSLPE PERNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKKIKL
     PKTYTQSNGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDIVN
     KRNPRLVPYN LLDEKTKKTN RDTVCAAVRT LIGYGYNIEP PDQESSGHVG NGTGNKIRVF
     RAEKSYAVTQ GKWYFEFEAV TVGEMRVGWA RPNVHADKEL GTDDLAYVFN GCKGQRWHVG
     SEPFGRQWQP GDVVGCMIDL AELNIMFTLN GEMLISDSGS EMAFKDIEIG EGFIPVCSLG
     LSQVGRINLG QNVSSLRYFT ICGLQEGFEP FAINMKRDIT MWFSKSLPQF IPVPTDHPHI
     EVSRVDGTVD SAPCLKLTHR TFGSQNANTD LLFFRLSMPI EFHESFKVEA GATPLTRALT
     IPEDEALEVD PNSEYELLKK SATRREQEEK EKEPSVPKEL PGTKEAENEK DTTTEKSKKR
     GFFSKAKKAA FITPPPVVPT VPRLMEDVVP DDRDDVDIIS NTTTHYYSVR VFAGQEPGGV
     WAGWVTPDYH YYDLHFDISK VRNVTVTVGD DKGNIHHSMK RSNCYMVWGG EFSGSQQTRI
     TQEDFVIGCL VDLDTGLMTF TANGKEVNTF YQVEPNTKLF PAVFCLPSSQ NMLQVELGKL
     KNIMPISAAM FRSDRRNPVP QCPPRLDVQM LTPVIWSRMP NRFLSHQTGR VSERLGWMVQ
     CTDPLTMMAL HIPEENRCID ILELSECTDL LKFHHHTLKL YGSVCALGNN RVAHALCSHV
     DESQLFYAIE NSYLPGPIRS GYYDLLISMH LESAKRNRLM TNREFIVPMT DETRSITLRA
     HTLPAVGRST CLRPTLQFSH TGFVGTNADL YTLSPFIPLQ TLKDHALSML TEAVQDGGQA
     MRDPVGGSVE FHFVPILKLI STLLIMGVFE DEDVKHILKL IEPTVFREEK GGQAEEDKSG
     EGTERQLASK EAGVEVKEKE ERVDGWTEDE GMGEEEEEEE ELEDDEEEEE DQTEQEDEEE
     HPAPEKADKE KAERREAEPQ AEPEAGPIVG REEPKEEEEV GEGLLHMKLP ESVKLQMCTL
     LQYFCDCELR HRVEAIVAFS DRFVTQVQSN QKQRYNQLMQ AFTMTAAETA RKTREFRSPP
     QEQVNMLMNF KNCPDEEDSP VPEEVRGELQ MFHNDLLAHC GIHVEEEEEE EHVDTSLRGR
     FFRLLEKVKR LRRRKQETEK EPEEEKKPST LQELISHTMI HWAQESFIQD PELVRLMFSL
     LHRQYDALGE LIRALPKAYT INAVSMQDTM ELLECLSQIR SLLIVQMGPE EERLMIQSIG
     NIMSNRVFYQ HPNLMRALGM HETVMEVMVN VLGGGDSKEI RFPRMVTNCC RFLCYFCRIS
     RQNQRSMFDH LSYLLQNSGI GLGMRGSTPL DVAAASCIDN NELALALQEQ DLEKVVKYLA
     GCGLQSCPML LSKGYPDIGW NPCGGEKYLD FLRFAVFVNG ESVEENANVV VRLLIRRPEC
     FGPALRGEGG NGLLAAIEEA IKISEDPARD GPTVKKDRRF PMFGGEEQHE ENRVHLGNAI
     MSFYAALIDL LGRCAPEMHL IQAGKGEALR IRAILRSLVP IEDLVGVISL PQQIPAFGKD
     NSIIEPKMSA SFVPDHKAPM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTAAFS
     TTEMALALNR YLCSAVLPLI TKCAPLFAGT AHRAIMIDSM LHTIYRLSRG RSLTKAQRDV
     IEECLMSLCK YLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA
     NFGVSSEEEL HLTRKLFWGI FESLAHKKFD AELFKIAMPC ICAIAGALPP DYVDASYCSK
     TEKKASVDAE GNFDPKPVDT TNTIIPEKLD GFINRYAEYT HDRWAFEKIQ SNWTFGEVLD
     ENAKTHPMLR PYKTFSEKDK EIYRWPIKES IKAMIAWGWT LDKARDGDED KGEKKAARKI
     SQTAQATYDP SHGYNPQPIN ISGMTLSREL QSMAEQLAEN YHNTWGRKKK MELQAKGCGT
     HPLLVPYDTL TAKEKARDRE KAHELLRFLQ LNGYAVTRGL KDMESDISSI EKRFAYGFLQ
     KLLKWMDIAQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLINQYFK NHCLYFLSTP
     AKILGSGGHA SNKEKEMIAS IFCKMSALVR HRVFLFGTDA PAIVNCLHIL ARSLDARTVM
     KSGPEIVKAG LRSFFESAAD DIEKMVENLK LGKVSKGNQP VKGVSQNINY TTVALLPVLT
     SLFDHIAQHQ FGDDVILDDL QMSCYRIMCS IYSLGTVKTP HAERHRPALG ECLAHLAAAM
     PVAYLEPHLN EYNAFSVYTT KTPRERAILG LPNEVQELCL DIPELDVLIR DIGHLAESGA
     RYTEMPHVIE VTLPMLCNYL PRWWERGVEN HPELEGKLCT HVTSEHLNQL LGSIMKIVVN
     NLGIDEAPWM KRLAVFSQPI VSRAKPEMLK SHFIPTMEKL KKRTAKVVAE EEHLRMEGKT
     EGDEEEGTIR DEFAVLCRDL YALYPLLIRY IDNNRARWLT CPDPDAEELF RMVGEVFIFW
     SKSHNFKREE QNFVVMNEIN NMSFLTADSK SKMSKAGGSD VERTKKKRRG DRYSVQTSLI
     VAALKKMLPI GLNMCSPADH ELINLAKFRY SLKDTDEEVR EFLQNNLHLQ GKVENPSMRW
     QMALYKMMAG KAEDADAPEK VVKRVQEVSA VLYHIEVTEH PFKSKKMVWH KLLSKQRRRA
     VVACFRMTPL YNLPSHRASN MFLDGYKRNW LHTEGLAFED RMIDDLSKAM EEEEEEEEEK
     ETKPDPLHQL ILHFSRTALT EKSKLDIDYL YMAYADIMAK SCHIGEEDEG GDEDQEGDEE
     EMSFEVRQSE TEKEMEKQRL LYQQSRLHNR GAAEMVLQMI SACKGETGCM VSSTLKLGIS
     ILNGGNSDVQ QKMLDYLKDK KDVGFFLSLQ TLMQTCCVLD LNAFERQNKA EGLGMVSEEG
     TNMKLERGEK VMADDEFTCD LFRFLQLLCE GHNNDFQNYL RTQTGSTTTI NIIICTVDYL
     LRLQESISDF YWYYSGKEII DEPGKRNFSK AMTVAKQVFN TLTEYIQGPC TGNQQSLAHS
     RLWDAVVGFL HVFAHMMMKL AQDSSQIGLL KELLDLQKDM VVMLLSLLEG NIVNGTIARQ
     MVDMLVESSS NVEMILKFFD MFLKLKDIVA SGAFRDYVTD PRGLISKKDF QKAMDSQKQY
     TPSEIQFLLA CSEADENEMI NYEEFASRFQ EPAKDIGFNI AVLLMNLSEH VPHDTRLQNF
     LEQAESVLNY FRPFLGRIEI MGASRKIERI YFEISEVNRK QWEMPQVRES KRQFIFDVVN
     EGGESEKMEL FVNFCEDTIF EMNIASQISE KEEEKEEDDE EVDEGNEAGG AGADDEDGDK
     NNQSESSSAF AEFLNSVVHF MGMFNFRNLR KQYRRLRKMT IKEISVGIAT FLWTILLGVF
     HFIFSVCKGF FLIVWHTLFG GSLVEGAKNI TVTELLASMP DPTQDEVHGD LPGEAGSGEE
     QEAGGVTDST EAAQGEEEYE DSTEQDVGKI PGIDTPGGLG DMGDTTPVEP PTPEGSPLTK
     RKMQPEEGGT EQTGAPEEPP PEPEKADTEN REKMEKEAEQ KTEGPQEKVM VQKPSKAKKE
     MKTIRDGGFE LWNELDVQRN KFMNYLSRNF YNLRFLALFI AFALNFILLF YRVSDTPPGD
     EELEGSGVFE GSGLFEGSGE QMDGSGAEDM GGDDDDDEDG PVYYFLEEST GYMQPTLSFL
     AIMHTVISFI CIIGYNCLKI PLVIFKREKE LARKLEFDGL YITDQPEDDD IKGQWDRLVL
     NTPSYPNNYW DKFVKRKVLD KYGDIYGRER IAELLGMDLA SLDVSKQQTD KKPQESDNSM
     LAWITSVDIK YQIWKFGVVF TDNTFLYLVW YTVMSLLGHY NNFFFACHLL DIAMGVKTLR
     TILSSVTHNG KQLMMTVGLL AVVVYLYTVV AFNFFRKFYN KSEDEDEPDM KCDDMMTCYL
     FHMYVGVRAG GGIGDEIEDP AGDEYELYRV VFDITFFFFV IVILLAIIQG LIIDAFGELR
     DQQEQVKEDM ETKCFICGIA SDYFDTTPHG FETHTLEEHN LANYLFFLMY LINKEETEHT
     GQESYVWKMY QERCWDFFPA GDCFRKQYED QLA
//
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