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Database: UniProt
Entry: A0A2D0SP48_ICTPU
LinkDB: A0A2D0SP48_ICTPU
Original site: A0A2D0SP48_ICTPU 
ID   A0A2D0SP48_ICTPU        Unreviewed;      5072 AA.
AC   A0A2D0SP48;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 4.
DE   SubName: Full=ryanodine receptor 1-like isoform X5 {ECO:0000313|RefSeq:XP_017344266.1};
GN   Name=LOC108276801 {ECO:0000313|RefSeq:XP_017344266.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017344266.1};
RN   [1] {ECO:0000313|RefSeq:XP_017344266.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017344266.1; XM_017488777.1.
DR   UniGene; Ipu.78417; -.
DR   GeneID; 108276801; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017344266.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4365   4383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4590   4610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4676   4697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4812   4830       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4874   4894       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4953   4976       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      592    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1348   1562       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      465    485       {ECO:0000256|SAM:Coils}.
FT   COILED     1888   1919       {ECO:0000256|SAM:Coils}.
FT   COILED     2101   2121       {ECO:0000256|SAM:Coils}.
FT   COILED     3701   3728       {ECO:0000256|SAM:Coils}.
FT   COILED     4287   4307       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5072 AA;  575312 MW;  75938CB9F3E4A3BF CRC64;
     MAEGGEGDEE IQFVRTEDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICVFILE QSLSVRALQE MLSHTSEDVD LDKWSSQGGG HRTLLYGHAI LLRHTHSGMY
     LSCLTTSRSL TDKLAFDVGL QEDSTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE
     RYLHLSYASG DLMVDASFMQ TLWNMNPVSS GCELVEGYLT GGYVLRLFHG HMDECLAIPA
     AEQGEERKNA HYEGGPVCSH ARSLWRLEPL RIGWSGGHIK WGQPFRVRHI TTGRYLCLDD
     EKGLLVVDPE KANTKSSAFC FRASKEKTEV AQKRDVEGMG APEIKYGESM CFVQHVATGL
     WLTYASVDAK SARLGPVKRK AILHQEGHMD DALTVARSQT EESQAARMIY STAGLFTQFI
     KSLDTLSGKN KSAAPPPPSL PLESVVLLLQ DLIFYFRPPD EDLEHEEKQS KLRSLKNRQN
     LFQEEGMITL VLDCIDRLNV YNTSAHFSEF AGEEAAESWK EIVNLLYELL ASLIRGNRAN
     CALFCDNLDW LVSKLDRLEA SSGILEVLYC ILIESPEVLN IIQENHIKSI IALLDKHGRN
     HKVLDVLCSL CVCNGVAVRS NQNLITENLL PRRDLLLQTQ IINYVTSMRP NIFLGTCEGS
     TQYKKWYYEL IVDHVEPFLT AQAGHLRVGW ALTEGYSPYP GGGEGWGGNG VGDDLYSYSF
     DGLHLWSGRV PRHVASPSQH ILAAEDVVSC CLDLSVPSIS FRINGHPVQG MFENFNLDGL
     FFPVVSFSAG IKVRFLLGGR HGDFKFVPPP GYAPCYEAVL PKDKLRIEPI KEYKNDLDND
     VRNLLGPTQS LSHTAFTPNP VDTVQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTYGP
     FRDDNKKLHP CLLDFQSLPE PERNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKKIKL
     PKTYTQSNGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDIVN
     KRNPRLVPYN LLDEKTKKTN RDTVCAAVRT LIGYGYNIEP PDQESSGHVG NGTGNKIRVF
     RAEKSYAVTQ GKWYFEFEAV TVGEMRVGWA RPNVHADKEL GTDDLAYVFN GCKGQRWHVG
     SEPFGRQWQP GDVVGCMIDL AELNIMFTLN GEMLISDSGS EMAFKDIEIG EGFIPVCSLG
     LSQVGRINLG QNVSSLRYFT ICGLQEGFEP FAINMKRDIT MWFSKSLPQF IPVPTDHPHI
     EVSRVDGTVD SAPCLKLTHR TFGSQNANTD LLFFRLSMPI EFHESFKVEA GATPLTRALT
     IPEDEALEVD PNSEYELLKK SATRREQEEK EKEPSVPKEL PGTKEAENEK DTTTEKSKKR
     GFFSKAKKAA FITPPPVVPT VPRLMEDVVP DDRDDVDIIS NTTTHYYSVR VFAGQEPGGV
     WAGWVTPDYH YYDLHFDISK VRNVTVTVGD DKGNIHHSMK RSNCYMVWGG EFSGSQQTRI
     TQEDFVIGCL VDLDTGLMTF TANGKEVNTF YQVEPNTKLF PAVFCLPSSQ NMLQVELGKL
     KNIMPISAAM FRSDRRNPVP QCPPRLDVQM LTPVIWSRMP NRFLSHQTGR VSERLGWMVQ
     CTDPLTMMAL HIPEENRCID ILELSECTDL LKFHHHTLKL YGSVCALGNN RVAHALCSHV
     DESQLFYAIE NSYLPGPIRS GYYDLLISMH LESAKRNRLM TNREFIVPMT DETRSITLRA
     HTLPAVGRST CLRPTLQFSH TGFVGTNADL YTLSPFIPLQ TLKDHALSML TEAVQDGGQA
     MRDPVGGSVE FHFVPILKLI STLLIMGVFE DEDVKHILKL IEPTVFREEK GGQAEEDKSG
     EGTERQLASK EAGVEVKEKE ERVDGWTEDE GMGEEEEEEE ELEDDEEEEE DQTEQEDEEE
     HPAPEKADKE KAERREAEPQ AEPEAGPIVG REEPKEEEEV GEGLLHMKLP ESVKLQMCTL
     LQYFCDCELR HRVEAIVAFS DRFVTQVQSN QKQRYNQLMQ AFTMTAAETA RKTREFRSPP
     QEQVNMLMNF KNCPDEEDSP VPEEVRGELQ MFHNDLLAHC GIHVEEEEEE EHVDTSLRGR
     FFRLLEKVKR LRRRKQETEK EPEEEKKPST LQELISHTMI HWAQESFIQD PELVRLMFSL
     LHRQYDALGE LIRALPKAYT INAVSMQDTM ELLECLSQIR SLLIVQMGPE EERLMIQSIG
     NIMSNRVFYQ HPNLMRALGM HETVMEVMVN VLGGGDSKEI RFPRMVTNCC RFLCYFCRIS
     RQNQRSMFDH LSYLLQNSGI GLGMRGSTPL DVAAASCIDN NELALALQEQ DLEKVVKYLA
     GCGLQSCPML LSKGYPDIGW NPCGGEKYLD FLRFAVFVNG ESVEENANVV VRLLIRRPEC
     FGPALRGEGG NGLLAAIEEA IKISEDPARD GPTVKKDRRF PMFGGEEQHE ENRVHLGNAI
     MSFYAALIDL LGRCAPEMHL IQAGKGEALR IRAILRSLVP IEDLVGVISL PQQIPAFGKD
     NSIIEPKMSA SFVPDHKAPM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTAAFS
     TTEMALALNR YLCSAVLPLI TKCAPLFAGT AHRAIMIDSM LHTIYRLSRG RSLTKAQRDV
     IEECLMSLCK YLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA
     NFGVSSEEEL HLTRKLFWGI FESLAHKKFD AELFKIAMPC ICAIAGALPP DYVDASYCSK
     TEKKASVDAE GNFDPKPVDT TNTIIPEKLD GFINRYAEYT HDRWAFEKIQ SNWTFGEVLD
     ENAKTHPMLR PYKTFSEKDK EIYRWPIKES IKAMIAWGWT LDKARDGDED KGEKKAARKI
     SQTAQATYDP SHGYNPQPIN ISGMTLSREL QSMAEQLAEN YHNTWGRKKK MELQAKGCGT
     HPLLVPYDTL TAKEKARDRE KAHELLRFLQ LNGYAVTRGL KDMESDISSI EKRFAYGFLQ
     KLLKWMDIAQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLINQYFK NHCLYFLSTP
     AKILGSGGHA SNKEKEMIAS IFCKMSALVR HRVFLFGTDA PAIVNCLHIL ARSLDARTVM
     KSGPEIVKAG LRSFFESAAD DIEKMVENLK LGKVSKGNQP VKGVSQNINY TTVALLPVLT
     SLFDHIAQHQ FGDDVILDDL QMSCYRIMCS IYSLGTVKTP HAERHRPALG ECLAHLAAAM
     PVAYLEPHLN EYNAFSVYTT KTPRERAILG LPNEVQELCL DIPELDVLIR DIGHLAESGA
     RYTEMPHVIE VTLPMLCNYL PRWWERGVEN HPELEGKLCT HVTSEHLNQL LGSIMKIVVN
     NLGIDEAPWM KRLAVFSQPI VSRAKPEMLK SHFIPTMEKL KKRTAKVVAE EEHLRMEGKT
     EGDEEEGTIR DEFAVLCRDL YALYPLLIRY IDNNRARWLT CPDPDAEELF RMVGEVFIFW
     SKSHNFKREE QNFVVMNEIN NMSFLTADSK SKMSKAGNAE AGGSDVERTK KKRRGDRYSV
     QTSLIVAALK KMLPIGLNMC SPADHELINL AKFRYSLKDT DEEVREFLQN NLHLQGKVEN
     PSMRWQMALY KMMAGKAEDA DAPEKVVKRV QEVSAVLYHI EVTEHPFKSK KMVWHKLLSK
     QRRRAVVACF RMTPLYNLPS HRASNMFLDG YKRNWLHTEG LAFEDRMIDD LSKAMEEEEE
     EEEEKETKPD PLHQLILHFS RTALTEKSKL DIDYLYMAYA DIMAKSCHIG EEDEGGDEDQ
     EGDEEEMSFE VRQSETEKEM EKQRLLYQQS RLHNRGAAEM VLQMISACKG ETGCMVSSTL
     KLGISILNGG NSDVQQKMLD YLKDKKDVGF FLSLQTLMQT CCVLDLNAFE RQNKAEGLGM
     VSEEGTSEKV MADDEFTCDL FRFLQLLCEG HNNDFQNYLR TQTGSTTTIN IIICTVDYLL
     RLQESISDFY WYYSGKEIID EPGKRNFSKA MTVAKQVFNT LTEYIQGPCT GNQQSLAHSR
     LWDAVVGFLH VFAHMMMKLA QDSSQIGLLK ELLDLQKDMV VMLLSLLEGN IVNGTIARQM
     VDMLVESSSN VEMILKFFDM FLKLKDIVAS GAFRDYVTDP RGLISKKDFQ KAMDSQKQYT
     PSEIQFLLAC SEADENEMIN YEEFASRFQE PAKDIGFNIA VLLMNLSEHV PHDTRLQNFL
     EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEVNRKQ WEMPQVRESK RQFIFDVVNE
     GGESEKMELF VNFCEDTIFE MNIASQISEK EEEKEEDDEE VDEGNEAGGA GADDEDGDKN
     NQSESSSAFA EFLNSVVHFM GMFNFRNLRK QYRRLRKMTI KEISVGIATF LWTILLGVFH
     FIFSVCKGFF LIVWHTLFGG SLVEGAKNIT VTELLASMPD PTQDEVHGDL PGEAGSGEEQ
     EAGGVTDSTE AAQGEEEYED STEQDVGKIP GIDTPGGLGD MGDTTPVEPP TPEGSPLTKR
     KMQPEEGGTE QTGAPEEPPP EPEKADTENR EKMEKEAEQK TEGPQEKVMV QKPSKAKKEM
     KTIRDGGFEL WNELDVQRNK FMNYLSRNFY NLRFLALFIA FALNFILLFY RVSDTPPGDE
     ELEGSGVFEG SGLFEGSGEQ MDGSGAEDMG GDDDDDEDGP VYYFLEESTG YMQPTLSFLA
     IMHTVISFIC IIGYNCLKIP LVIFKREKEL ARKLEFDGLY ITDQPEDDDI KGQWDRLVLN
     TPSYPNNYWD KFVKRKVLDK YGDIYGRERI AELLGMDLAS LDVSKQQTDK KPQESDNSML
     AWITSVDIKY QIWKFGVVFT DNTFLYLVWY TVMSLLGHYN NFFFACHLLD IAMGVKTLRT
     ILSSVTHNGK QLMMTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF
     HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI VILLAIIQGL IIDAFGELRD
     QQEQVKEDME TKCFICGIAS DYFDTTPHGF ETHTLEEHNL ANYLFFLMYL INKEETEHTG
     QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LA
//
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