ID A0A2D0SPD6_ICTPU Unreviewed; 2540 AA.
AC A0A2D0SPD6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Talin-1 isoform X2 {ECO:0000313|RefSeq:XP_017344564.2};
GN Name=tln1 {ECO:0000313|RefSeq:XP_017344564.2};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017344564.2};
RN [1] {ECO:0000313|RefSeq:XP_017344564.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017344564.2};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017344564.2; XM_017489075.3.
DR STRING; 7998.ENSIPUP00000002353; -.
DR OrthoDB; 25353at2759; -.
DR Proteomes; UP000221080; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17171; FERM_F0_TLN1; 1.
DR CDD; cd17173; FERM_F1_TLN1; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 7.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981; TALIN; 1.
DR PANTHER; PTHR19981:SF7; TALIN-1; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 2.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 1.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR SUPFAM; SSF109885; I/LWEQ domain; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 86..403
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 554..830
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT DOMAIN 2290..2529
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 1023..1069
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2497..2524
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2540 AA; 270920 MW; 72C470D3BCDEEFFE CRC64;
MVALSLKIGV GNVIKTMQFE PSTMVYDACR VIRERVPEAQ LGQPNDYGLF LSDDDPKKGI
WLEAGKALDY YMLRNGDTLE YKKKQRPLKI RMLDGTVKTV MVDDSKIVTD LLMTICARIG
ITNHDEYSLV RDIGEEKKEE ITGTLKRDKT LLRDDKKMEK LKQKLHTDDE LNWLDHGRTL
REQGVEETEM LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG
YQCQIQFGDH NEAKHKPGFL DLKEFLPKEY VKNKGEKKIF QAHKNYQNMT EIEAKVSYVK
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVMQE WSLTNIKRWA
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML
EDSVSPKKST VLQQQFNKVE RVETGSVALP VIMRPGAGGP ESFQMGSMPQ AKQHITSGQM
HTGHMPPLTS AQQALTGTIN SSMQAVQAAQ ASLTDFDTLP PLGTDAASQA WRKNKMDESK
HEIHSQVDAI TAGTASMVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSKG VKLLAALMED
EGGNGQQLLG AARNLACAVS DMLKTAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDA
DQQFQDMLMK LAKAVATAAA TLVLKAKNVA QKTEDSAQQN RVIAAATQCA LSTSQLVACT
RVVAPTISSP VCQEQLIEAG KLVAKSVEGC VEASQGATND EQLLKQVGVA ATGVTQALNE
LLQHIKQYAS GGQPIGRHGE ATDRILDVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI
KADAEGETDL ENSRKLLSAA KLLADATAKM VEAAKGAAAN PDSEEQQQKL REAAEGLRMA
TNAAAQNAIK KRLVNKLENA AKQAAAAATQ TIAAAQHAAS SNKNPAAQQQ LVQSCKVVAE
QIPQLVQGVR GSQAQPDSPS AQLALIGASQ NFMQPGAKMV TAAKATVPTI SDQATAMQLS
QCAKNLANAL AELRTAAQKA QEACGPLEID NALNMVRGLE KDMQEAKASA AEGKLRPLPG
ETLEKCSQDL GSNTKAVSSA VAQLLSEATQ GNENYTGMAA RDVAQALRSL ASAARGVAAN
TKDPQACNAM LDCARDVLDK SGNLIEETKR AIAKPGDPDS QQRLAQVAKA VSQALNRCVN
CLPGQRDVDN AIRTVGEASK KLLSDQFPAS GKSFQEAQAN LNQAAAGLNQ SANELVQASR
GTTQDLAKAS GKFGQDFSHF LEAGVDMAGQ SQSKEDQTQV VTNLKTISMS SSKLLLAAKV
LSTDPNSPNL KNQLAAAARA VTDSINQLIT MCTQQAPGQK ECDNALRELE TVRGMLENPT
EAVSDMGYFD CIDSVMENSK VLGEAMAGIS HNAKNSNLPE FGDAVSSASK ALCGLTEAAA
QGAYMVGVSD PNSHAGQKGL VDPAQFAKAK QSIQMACQNL VDPACTQSQV LSAATIVAKH
TSALCNACRL ASSKTSNPVA KRQFVQSAKE VANSTANLVK SIKALDGAFN QENRQKCKAS
TGPLIEAVDN LAAFASNPEF ASVPAQISPE GLAAMEPIVA AAKTMLESST GLIQTARSLA
VNPKDPPKWS VLAGHSRTVS DSIKKLITNM RDKAPGQREC DEAIEVLNNC IREVDQASLA
AISQQLAPRD DISHEALHEQ MAASVQEISH LIDPVAIAAR SDASQLGHKV SQMASYFEPL
IMASIGTASK ILNSQQQMSV LDQTKTLAES ALQMLYTAKE AGGNPKAAHT QEALEESVQM
MKEAVDDLGG TMAEAASAAG AVGGMVDSIT QALNKLEDPG VEPEGSFVDY QTTMVKTAKA
IAVTVQEMVT KSNTNPDELG GLANQLTTEF GDLASEAKCA VITAESDEIG SHIKKQVTDL
GYSCTGLVTK AGALQCSPND SITKKELIDA ARKVSEKVSH VLAALQAGNR GTQACITAAS
TVAGIIADLD TTIMFATAGT LNRENAETFA DHRENILKTA KVLVEDTKLL VSGAGASQEK
LAQAAQSSVN TITKLADVVK LGAASLGSED PETQVVLINA VKDVAKALGD LIRATKAAAG
KPHDDPAMLQ LKSSAKVMVT NVTSLLKTVK AVEDEATKGT RALEATIEHI KQELTVFSSL
DPPPKTATPE EFIRMTKGIT QATAKAVAAG NSCRQEDIIA TANLSRRAIA EMLHSCKQAA
YHPEVNQEVQ TRALRFGTEC ATGYLALLEH VLVIIQKPTH DLKQQLAIFS KRVAGSVTEL
IQAAEAMKGT EWVDPEDPTV IAENELLGAA AAIEAAAKKL EQLKPRAKPK EADESLNFEE
QILEAAKSIA AATSALVKAA SAAQRELVAQ GKVGAIPANA VDDGQWSQGL ISAARMVAAA
TNNLCEAANS AVQGHASEEK LISSAKQVAA STAQLLVACK VKADQDSQTM KRLQAAGNAV
KKASDNLVKA AQKAAFDAQD DQAVMVKSKM VGGIAQIIAA QEEMLRKERE LDEARRKLAQ
IRQQQYKFLP SELREDGHEQ
//