ID   A0A2D0SPG8_ICTPU        Unreviewed;       946 AA.
AC   A0A2D0SPG8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=PH and SEC7 domain-containing protein 3 isoform X3 {ECO:0000313|RefSeq:XP_017344603.1};
GN   Name=psd3l {ECO:0000313|RefSeq:XP_017344603.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017344603.1};
RN   [1] {ECO:0000313|RefSeq:XP_017344603.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017344603.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}.
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DR   RefSeq; XP_017344603.1; XM_017489114.3.
DR   AlphaFoldDB; A0A2D0SPG8; -.
DR   GeneID; 108276947; -.
DR   CTD; 559329; -.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000221080; Chromosome 16.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13295; PH_EFA6; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
FT   DOMAIN          451..637
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          688..801
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          35..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..928
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        929..946
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  104914 MW;  529520C0A70A8A92 CRC64;
     MEQRDGAEAF VWVNGSSSHA QSVAKAKYEF LFGKTHDASS PGTASTCDSN PLLEDNISTT
     PDPSIQEDEL DETSLFQEID RELAELLSGL TARARDAAAA EQHSQSGDAT SDMIPCNGTP
     PSPPGTADHA SELQNGTSDS GQTEQLKDVT FDSWCEALIQ DPSSAQELQC ASPALDPDTR
     NAPASQHKPA PVPVTEKQEG GESADLSPKL LDASLDESSK ILAEIPGIFS AFLDGGKARE
     KTQKKLRFVE DQADAEVFLN GKAEEKEQTT QDMEKPSQDN TLKAAVPVMC VSEATENSSA
     RSVEARASES EEATDVFSSQ FESILESERL CVTLYSSLDS LDALTSSADE TDEQAVPAHA
     HRVVEMPLTP MIQQRLKESG LFMEASRRQE EVLSVSVTGK SGKAALEVTS SFLNTSTEQV
     DSIAGHTDGA LANGMMGKET SDWLQSWTSS DEGLKDVLSD WDLDMGSTER QKDSTDTLNN
     GHRSDQEAAR RLARRLYHLE GFRRSDVAMH LGKNNDFSKM VAEEYLTFFE FTGMTLDQSL
     RSFLKAFALM GETQERERVL IHFSNRYYQC NPTILASQDE VHCLTCALML LNSDLHGQNI
     GKKMTCQEFI NNLDGLNAGQ DFPRDLLKAL YNSIKNEKLE WAIDGDELKK SLSELADTKN
     DNAHTKSISR ISSSSNPFLD IAHDPNAAVY KAGFLARKIH ADMDGKKTPR GKRGWKTFYA
     VLKGMILYLQ KDEYKPEKAL SEEDLKNAIS VHHALAIKAV DYEKKPNVLK LKTADWRVFL
     FQAQSPEEME SWIRVINSVA AMFSAPSFPA AIGSQKKFSR PLLPATTTRM SQEEQLKSHE
     AKLKHICTEL AEHRSYPPDR KVKAKEVDEY RLKEHYLEFE ENRYETYVKL LKDGVKEVLS
     AKENDAALKK SQSSPHLNQE SQPAAAKIKR NTSERKDYRP ETPKVT
//