ID A0A2D0SU81_ICTPU Unreviewed; 2804 AA.
AC A0A2D0SU81;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Neurofibromin isoform X1 {ECO:0000313|RefSeq:XP_017346252.1};
GN Name=nf1a {ECO:0000313|RefSeq:XP_017346252.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017346252.1};
RN [1] {ECO:0000313|RefSeq:XP_017346252.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017346252.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017346252.1; XM_017490763.3.
DR GeneID; 108277815; -.
DR KEGG; ipu:108277815; -.
DR CTD; 326708; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000221080; Chromosome 17.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1150..1366
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1495..1653
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2768..2804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2768..2798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2804 AA; 315980 MW; 714F8256C1FCF8F9 CRC64;
MAAHKPVEWV QAVINRFDEQ LPIKTGHQNT HTKVSTEHNK ECLINISKYK FSLVINGLTN
ILKNVNNMRI IGEAGEKNLY LSQLIILDTL EKCLAGQTKD CLRLDEAMLV KQLLPEICHF
LHSCREGQQH ATQLRSSASA VLFSLSCNNF SAVFSRISTR LQELTVCTED TVDVHDIELI
QYINVDCSKL KRLLQETVLK FKALKKPAQL AVINSLEKAF WNWVEYYPDE FTMLYQRPQA
DMADSAEKLF DLVDSFAESA KRKAAVWPLQ IILLILCPEI TQSISKEVVE ESKANKKLFL
ESLRKALAGH SSSKQLTESA AIACVKLSKA CTYINWEDHS VIFLLVQSIV MDLKALLFNP
TKPFSRGTGC QSADVDLMID CFVSCFRINP HNNQHFKVCL ASTSPPTFHF VLVNSLHKII
TNSHLDWWPK IDTIYCYSGE LRAMFADTQA RVVQSLTAHA PLRMTPSLTF KEKMTTSLKF
KEKSADLDSR SLLLALVKLI HADPKLMLHN PGKQGQEIQN STAELIIGLI QLVPLTHTSE
LSQEAMEALL VLHQPETIEL WNPDAPIETF WDISSQVLFL ICKKLIGHQM INSTEILKWL
REILICRNKF LLKNKESATQ GSLIPISRQA QTKLEVCLYS FLWSPDAEAV LVAMSCFRHL
CEEADVRCSV DELPVHTVLP NYNTFMEFAS VSNMMATGRS TLQKRVMALL RRIEHPTAGN
TEAWEDTLAK WEQATKQILN HPKNKVEDGQ EWINMTGFLC ALGGVCLQQR STPSLGTYSP
PLGPMSERKG SMISMGSCEV NSETPLSRFL ERLLSLMVCT HEKVGLHIRT NVKDLLGLEL
SPALYSMLFT KLRNSIGRFF DTQGPVPIND TNTLFVEQTI AIMKNLLDSH TEGSSEHLGQ
ASIETMMLNL VRYVRILGNG VHAIQIKTKL CQLVEVMMER RDDLSFCQEM KFRNKMVEYL
TDWVMGTSNQ AADDDVKYLT RDLDQASMEA VVSLLAGLPL QPEEGDGVEL MEAKSQLFLK
YFTLFMNLLN DCSEVEEDGQ QVGERKRGMS RRLASLRHCT VLAMSNLLNA NVDSGLMHSI
GLGYHKDLQT RATFMEVLTK ILQQGTEFDT LAETVLADRF ERLVELVTMM GDQGELPIAM
ALANVVPCSQ WDELARVLVT LFDSRHLLYQ LLWNMFSKEV ELADSMQTLF RGNSLASKIM
TFCFKVYGAA YLQKLLEPLM RGVITSPEWQ HISFEVDPTR LEPSENLEEN QRNLLQITDR
FFLAIINSSS EFPPQLRSVC HCLYQATCHS LLNKATVKEK KENKKSVVSQ RFPQNSIGAV
GSAMFLRFIN PAIVSPYEAG ILDKKPPPRI ERGLKLMSKI LQSIANHVLF TKEEYMRPFN
DFVKNNFEAA RRFFLDIASD SPPSDSVNHS LSFISDGNVL ALHRLLWNNQ ERIGQYLSSN
RDHKAVGRRP FDKMATLLAY LGPPEHKPVA DTHWSSLNLT SSKFEEFMTR HQVHEKEEFK
ALKTLNIFYQ AGTSKNGNPV FYYIARRFKT GQINGDLLIY HVLLTLKPYY AKHYEIVVDL
THVGPSNRFK TDFLSKWFVV FPNFAYENVA AVFIYNCNTW VREYTKYHER LLTGLKGSKK
LLFIDSPARL AEYVEPDQQK LPASTLALEE DLKVFHNALK LAHKDTKVSI KVGSTAVQVT
SAERTRVLGQ SVFLNDIYYA SEIEEICLVD ENQFTLTIAN QGTPLTFMHQ ECDAIVQSII
HIRTRWELSQ PDSIPQHTKI RPKDVPGTLL NIALLNLGSS DPSLRSAAYN LLCALTCTFN
LKIEGQLLET SGLCIPANNT LFIVSISKTL AANEPHLTLE FLEECISGFS KSSIELKHLC
LEYMTPWLRN LVRFCKHNDD AKRQRVTAIL DKLITMTINE KQMYPSIQAK IWGSLGQISD
LLDVVLDSFI KTSATGGLGS IKAEVMADTA VALASGNVKL VSSKVIGRMC KIIDKTCLSP
TPTLEQHLMW DDIAILARYM LMLSFNNSLD VAAHLPYLFH VVTLLVATGP LSLRASTHGL
VINIIHSLCT CSQLNFSEET KQVLRLSLTE FSLPKFYLLF GISKVKSAAV IAFRSSYRDR
SFSPGSYERE TFALSSLETV TEALLEIMEA CMRDIPGCKW LDQWTELAQK FAFQYNPSLQ
PRALVVFGCI SKRVTHGQIK QIIRILSKAS PLLSIDRGLE SCLKGPDNYN SQVLIEATVI
ALTKLQPLLS QDSPMHKALF WVAVAVLQLD EVNLYSAGTA LLEQNLHTLD SLRVFNDKSP
EEVFMEIRKP LEWDCKQMDH FVGLNFNSNF NFALVGHLLK GYRHPSSTTV ARTVRILHTL
LGLVGKHRNC DKFEVNTQSV AYLAALLTVS EEVRSRCSLK HRKSLLLSDV TMENFPVDTY
SVYHPEPGCR PLKESQPWTS PKVSERYLAA YYPTMGQTSP RTRKSMSVDM GQPSQANAKK
LLGTRKSFDH LISDSKAPKR PEMETGITTP PKIRRVAEND YDIETQRIAN SHLRKVSVSE
SNVLLDEEVL TDPKIQMLLL TVLATQVKYS TDEFHQRILY EYLAEASVVF PKVFPVVHNL
LDSKISTLLS MCQDPNLLNP VHGIVQSVVY HEESPPQYQP SCLQSFGFNG LWRFAGPFSK
QTQIPDYAEL VVKFLDALID TYLPGIEEEG GEESQRTPTS PYPPIVQSQL SITANLNLSN
SMTSLATSQH SPEGPIVYRR SPTLSHARTS EEMPPKTAAS LPCSKSTVFP PHLVFPAGID
KENVELSPTS SLCSSGRARH GSASQVQKQR STGSFKRTSI KKIV
//
