ID   A0A2D0SUH2_ICTPU        Unreviewed;       486 AA.
AC   A0A2D0SUH2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X2 {ECO:0000313|RefSeq:XP_017345955.1};
GN   Name=nherf4a {ECO:0000313|RefSeq:XP_017345955.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017345955.1};
RN   [1] {ECO:0000313|RefSeq:XP_017345955.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017345955.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NHER family.
CC       {ECO:0000256|ARBA:ARBA00038110}.
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DR   RefSeq; XP_017345955.1; XM_017490466.2.
DR   AlphaFoldDB; A0A2D0SUH2; -.
DR   GeneID; 108277664; -.
DR   CTD; 557269; -.
DR   OrthoDB; 2914289at2759; -.
DR   Proteomes; UP000221080; Chromosome 17.
DR   CDD; cd00992; PDZ_signaling; 4.
DR   Gene3D; 2.30.42.10; -; 4.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR14191:SF3; GH04176P; 1.
DR   PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00595; PDZ; 4.
DR   SMART; SM00228; PDZ; 4.
DR   SUPFAM; SSF50156; PDZ domain-like; 4.
DR   PROSITE; PS50106; PDZ; 4.
PE   3: Inferred from homology;
FT   DOMAIN          31..113
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          125..223
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          251..334
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          375..455
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
SQ   SEQUENCE   486 AA;  53954 MW;  023D5923D954CC80 CRC64;
     MPQKFTFNPK EGIDNPVLMI SDDPEPNLCP RLCLLKREEG QGFGFNLRKE SGCRGHVVQQ
     VAPWSAAERS GLRDGDRILE VNEDFVDNQE YSKVVLKVQA SGLQLCLLVL SAVEYETAVC
     EGIDLMALSR ANRGEGCVRP RLCHISREPG IGLGLNIFPI EGKRGKYYLS PVSEGPAERA
     GVQAEDHLLS INGVMVSKLT HSALMKMFKK CGECVTILVI DSRSEESYMR RRLPILPTFA
     STHNLPHRPK TLHLTQGPQG YGFLLRQEKL TTGHIAHLLR EVDPCSPAEA AGMEDGDLLL
     AVNGEQVENS EHEDIVSRIR QSGQQVTLTT ISIHGREYYT QLGLSPLIFY EEYIPQRERF
     STNTLPSNNL PRPRLCTLHR EDTGFGFKLA CSQNECRVYV VQVEAGHAGE RAGLREGDVI
     VEVNGQNVEH ENFEKVVTLI KKGGTSLMLL VVDKDGFEKL STSVPITPDV SLHSTQVPDS
     TQDNFV
//