ID A0A2D0SUW8_ICTPU Unreviewed; 754 AA.
AC A0A2D0SUW8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=ARF GTPase-activating protein GIT1 isoform X3 {ECO:0000313|RefSeq:XP_017346479.1};
GN Name=git1 {ECO:0000313|RefSeq:XP_017346479.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017346479.1};
RN [1] {ECO:0000313|RefSeq:XP_017346479.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017346479.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017346479.1; XM_017490990.3.
DR AlphaFoldDB; A0A2D0SUW8; -.
DR GeneID; 108277930; -.
DR CTD; 28964; -.
DR OrthoDB; 2877020at2759; -.
DR Proteomes; UP000221080; Chromosome 17.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF1; ARF GTPASE-ACTIVATING PROTEIN GIT1; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..124
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 166..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 354..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..472
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 355..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 82183 MW; 49637355135D80A4 CRC64;
MSRKVQRSEV CADCSAPDPG WSSINRGVLI CDECCSVHRS LGRHISIVKH LRHSGWPPSL
LQMVQTLASN GANSIWEHSL LDPAQVQSGR RKPNPQDKVH PTKSEFIRAK YQMLAFVHKL
PCRDDDGVTS KDLSKQLHSS VRTGSLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQV
LQAELLVVYG ADPGAPDING RTPMDYARQA GQVELAERLV ECQYELTDRL AFYLCGRRPD
HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LNNRLFEELA MDVYDEVDRR ENDAVWLTTQ
NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSD AKRRQQGKGL
TSPTEPLDAS QADDDQHDYD SVASDEDTDS EITAQNNTNA QRNNRAKSMD SSDLSDGPIT
LQEYLEVKKA LASSEAKVQQ LMKVNNNLSE ELRRLQKEIS RMQTENVALK GAQAGPAGAL
GGGNPALWPM GVRGGAGGVG SGDSSLAPPS SAPLRRDRQA FSMYEPGTAA PKALGPALDS
LSGHLQPLSS SVSVRKGASA GPTPYGGPHM SASMEMGRYM PPKLEKHGSG TDSDYDNTQT
YDTSIGVGRS SEEESRAEED SGDAGEPDPT LPCTEDVILK TEQVTKNIQE LLRAAQEFKH
DSFVPCSEKI HSAVTEMASL FPKRPALDAV RASLKLLASS ASRLQVECRK AAPSEPSASA
VDYQLLTQQV IQCAYDIAKA AKQLVTITTR EKKQ
//
