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Database: UniProt
Entry: A0A2D0SV12_ICTPU
LinkDB: A0A2D0SV12_ICTPU
Original site: A0A2D0SV12_ICTPU 
ID   A0A2D0SV12_ICTPU        Unreviewed;      1538 AA.
AC   A0A2D0SV12;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-OCT-2019, entry version 12.
DE   SubName: Full=rho GTPase-activating protein 35 {ECO:0000313|RefSeq:XP_017346360.1, ECO:0000313|RefSeq:XP_017346361.1};
GN   Name=arhgap35 {ECO:0000313|RefSeq:XP_017346360.1,
GN   ECO:0000313|RefSeq:XP_017346361.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017346361.1};
RN   [1] {ECO:0000313|RefSeq:XP_017346360.1, ECO:0000313|RefSeq:XP_017346361.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017346360.1,
RC   ECO:0000313|RefSeq:XP_017346361.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017346360.1; XM_017490871.1.
DR   RefSeq; XP_017346361.1; XM_017490872.1.
DR   GeneID; 108277872; -.
DR   KEGG; ipu:108277872; -.
DR   CTD; 2909; -.
DR   KO; K05732; -.
DR   OMA; WAPGSDG; -.
DR   OrthoDB; 110157at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 3.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080}.
FT   DOMAIN      268    326       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      428    482       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      484    549       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      593    773       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      802    972       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1265   1452       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      990   1013       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1078   1169       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1197   1225       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1499   1538       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      419    439       {ECO:0000256|SAM:Coils}.
FT   COILED      477    497       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1125   1158       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1204   1225       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1505   1522       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1538 AA;  173503 MW;  CDCA6AA593E08F5E CRC64;
     MMAKKHDARA PTYNLVVVGL SGTEKEKGQC GVGKSCLCNR FVRPSADDFY LDHTSVLSTS
     DFGGRVVNND HFLFWGEASR PLEEGPECRM HVVEQTEFID DQTFQPHRST ALQPYIKRAA
     STKLASAEKL MYFCTDQLGL EQDFEQKQMP EGKLLVDGFL LCVDVSRGMN RNFDDQMKFI
     SNLYNQLAKT KKPVVLVLTK CDEGVERYIK DSHTFALAKK NLQVVETSAR SNVNVDLAFL
     TLVQLIDKSR GKPKIIPYFE ALKQQSQQIA SAKDRYEWLV SCIVKNHNET WPNINRRMQT
     SPEYKDYVFL EGTSKAKKLF QQHVHRLKQD HIEKRRRIYL STLPQALCTL VPDLDEIDHL
     SWSGVQKVLE TKRGFSQWFV ILDDTPWETT PHIDNMEDER IPQDLLETPA AEVIYESHLE
     HLRNERKRAE MRREFKEKLV ASPFVTPGKP WEEARSFIMN EEFYQWLEEP EYLDMYNKHQ
     KEIIDQAKED FQELLLEYSE LFYELEVDAK PSKEKMGAIQ EVLGEEQRFK ALQKLQAERD
     ALVLKHIHFV YHPTKETCPN SPYCVDSKIE QILATRFPTR YAFDGTLKSQ YGEGKVDRIN
     LVILGKDGLA RELANEIRAM CTSDDRYTLD GKTYELALRP IEGNVRLPVN SFHTPTFTPH
     GCLCLYNSKE SLSYVVESIE KLRESTIGRR DNSLALLPMS LLLVTKRGVG SIGDIGGETA
     QSLIIQGQQV AGKLQCAYLD PASPGAGYAR NLNEKQINQV LKSLLDVQRP LGSLGSSSPP
     LPAPRARFRD SHAQQTSEAD LHVVMCIMCG DTYDVDQLLS PFLHSQHCRP SANLSSGTSV
     LLDLTIGSQR QTIDLAVLSY HSTFSLRKSR LVHGYIAVYS AKRKASLETL CAFLCEVQDI
     IPVQLLAVGE TQAELTESEV ARDQLVEGEE LAHEIEGRFS SVVCGPGGVV GGLHRIDLFQ
     PFLKEVVEKR TIVEATHMYD NVAEACSTNE SVHSPRCGSP SVPMLDSEDD VEPSPPCPIY
     RDDSTLTHGF KFSDLESSDT FSVISEISTF ESKLNNKVPP QVRPKPTVTF GKVSLGSYMD
     HGGNRRSLPS VTWPPSSDGG YDPSDYSEPV DAVPKPRPTE EENIYSVPHD STQGKIITIR
     NANKSHSNGG GNGSDSEADN SSLERRRNLS TVGIKPRLYR DRSKRLGKFS NFRTSFIGSD
     DELGGPPKTK EDEMGIQKGD NSLNEECEDP KRNKILRSLR RTGKKTRPKP RQSISKQLES
     NYFGVPLVNV VTAERPIPLF IEKCIRYIEA TGLSTEGIYR VSGNKAEMES IQRQFDQDSN
     LDLVEKDFSV NTVAGAMKSF FSELPDPLVP YNMQVELVEA FKINDREQRF LTMKDVLRRF
     PRENYDVFKY VISHLNKVSQ NSRVNLMTSD NLSICFWPTL MRPDFTTMDA LTATRTYQTI
     IETFIYQCAF FFYNQPLVDT TSGLPGLPGS PTATLSSTTS MSGSAYSSCY TPVQHVATPF
     SQSQQSPPHS PPPTPQSPIQ SLLPPMHPHH TSTEQHTL
//
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