ID A0A2D0SWW1_ICTPU Unreviewed; 361 AA.
AC A0A2D0SWW1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
GN Name=LOC108278278 {ECO:0000313|RefSeq:XP_017347016.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017347016.1};
RN [1] {ECO:0000313|RefSeq:XP_017347016.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017347016.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}.
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DR RefSeq; XP_017347016.1; XM_017491527.2.
DR AlphaFoldDB; A0A2D0SWW1; -.
DR STRING; 7998.ENSIPUP00000013415; -.
DR Ensembl; ENSIPUT00000013979; ENSIPUP00000013415; ENSIPUG00000009171.
DR GeneID; 108278278; -.
DR KEGG; ipu:108278278; -.
DR OMA; LWEPQPE; -.
DR OrthoDB; 2914289at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF4; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|PIRNR:PIRNR037866}.
FT DOMAIN 9..89
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 172..252
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 108..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39956 MW; ECE339D8160FB8B6 CRC64;
MASDLKPRLC CMTKGENGYG FHLHGEKGKT GQYIRKVEHP SPAEESGLRA GDRVVEVNGE
NVERETHQQV VQRIKAMEHE TRLLVVDRET DEYLRSLRLT CTEDMAVRVS PSASSSSPPP
THSKRENNSV SKLPTSREIP KPSRRSPSRA TKKEAPVMPS VPADVSELVP RLCHLVRAET
GYGFNLHSEK SRPGQYIRSL DPSSPADRAG LRPQDRLIEV NGVNIEGMRH AEVVAFIKRG
GDETHLLVVD PDTDEHFKKL GITPSSSHVK GFEGQTITNG SPNPRVNGHS TQSAHSDHSS
QDTSTQNSED GDSHSLDPFA EIGLRLSPTA AEAKEKAHAK RGKKRAPQMD WNKKYEIFSN
F
//
