ID A0A2D0SZH8_ICTPU Unreviewed; 451 AA.
AC A0A2D0SZH8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Lipase member H isoform X2 {ECO:0000313|RefSeq:XP_017348083.1};
GN Name=lipia {ECO:0000313|RefSeq:XP_017348083.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017348083.1};
RN [1] {ECO:0000313|RefSeq:XP_017348083.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017348083.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR RefSeq; XP_017348083.1; XM_017492594.3.
DR AlphaFoldDB; A0A2D0SZH8; -.
DR STRING; 7998.ENSIPUP00000027545; -.
DR Ensembl; ENSIPUT00000028665; ENSIPUP00000027545; ENSIPUG00000018658.
DR GeneID; 108278894; -.
DR CTD; 445105; -.
DR OMA; DALHTDM; -.
DR OrthoDB; 3428256at2759; -.
DR Proteomes; UP000221080; Chromosome 18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..451
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012452102"
FT DOMAIN 41..328
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 158
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 182
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 252
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 196
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 198
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 201
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 451 AA; 51460 MW; 72098F0550656187 CRC64;
MMFRITHCLL IAIILMPFTI CRGEECEQIT DLDLKHSIVG TSLVVRLILY TRENVTCGKV
LSYEDISATP TFNRSRPCTF LIHGYRPTGS PPIWMNRIVE SILRRRDINV IVVDWNRGAT
NINYLQVVKN TRPVANNITH FIKQAGLNLS SIHMIGVSLG AHISGFTGAN FNGSIGRITA
LDPAGPSFRG TSPDERLDPS DAHFVDALHT DMDAFGYRDS LGHIDYYANG GSDQPGCPKS
IFSGSKYFKC DHQRSVFLYL DSINQSRQIT AYPCSDYSDF LDGKCLSCER FNSSGCPVFG
YDVTKWKDVL LKLRQTTTFF TTNQEAPYCK SGYKVEIVSW NSEVRWGTIT IMLKNSAQET
ETQIDHKSFK FERYTETMLL AQFKQDIYPV EKITLKYVTA NVFTHRYKLR VLRFRLTPLK
IGLRPMCRYD LLLEENKEVT FRPIPCHDSN F
//
