ID A0A2D0T1E4_ICTPU Unreviewed; 136 AA.
AC A0A2D0T1E4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Vascular endothelial growth factor A {ECO:0000313|RefSeq:XP_017348737.1};
GN Name=LOC108279200 {ECO:0000313|RefSeq:XP_017348737.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017348737.1};
RN [1] {ECO:0000313|RefSeq:XP_017348737.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017348737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
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DR RefSeq; XP_017348737.1; XM_017493248.3.
DR AlphaFoldDB; A0A2D0T1E4; -.
DR STRING; 7998.ENSIPUP00000030754; -.
DR Ensembl; ENSIPUT00000031987; ENSIPUP00000030754; ENSIPUG00000020762.
DR GeneID; 108279200; -.
DR KEGG; ipu:108279200; -.
DR OMA; TRTHIQE; -.
DR OrthoDB; 4231319at2759; -.
DR Proteomes; UP000221080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR12025:SF14; SNAKE VENOM VASCULAR ENDOTHELIAL GROWTH FACTOR TOXIN VR-1'-LIKE ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..136
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012745400"
FT DOMAIN 36..133
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 136 AA; 15818 MW; 9ACE61FABD2B3BA1 CRC64;
MSQVLLWLLL VVTLPLQTCR GDKSQGYNED TRETSNKGKT MEDLKKQSDC QPRESLINVY
DEFPDEIQYT IVPHCVPLQR CLGCCTDEEQ MCMPKRTETV NLEVFRTYSN GTSEIIKLPF
LKHTRCQCRH QKKSNN
//
