ID A0A2D0T1W9_ICTPU Unreviewed; 375 AA.
AC A0A2D0T1W9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nodal-related 1 {ECO:0000313|RefSeq:XP_017348909.1};
GN Name=ndr1 {ECO:0000313|RefSeq:XP_017348909.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017348909.1};
RN [1] {ECO:0000313|RefSeq:XP_017348909.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017348909.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_017348909.1; XM_017493420.3.
DR AlphaFoldDB; A0A2D0T1W9; -.
DR STRING; 7998.ENSIPUP00000007149; -.
DR Ensembl; ENSIPUT00000007462; ENSIPUP00000007149; ENSIPUG00000004944.
DR GeneID; 108279289; -.
DR KEGG; ipu:108279289; -.
DR CTD; 799352; -.
DR OMA; LDWERAG; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000221080; Chromosome 18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013220478"
FT DOMAIN 241..375
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 231..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 41853 MW; 45DDE974EB9387AD CRC64;
MKQLVCGILC VALWVRSVSA SARVGRKRGS AKGPYPLYMM HLYRTLLAGD GKKSAGTSSA
GVGYELPSLH HSDSVLSLVA KSCYQVGDKW AVTFDMSSIS ASDDVRHSEL RLRLPEFSAS
EHPMVDIYHA PKGAEERLHL GRIDNTSSTS TSSHSSWRVL NITQLLKYWL HQGGLPPTQV
RLDDGAPQDL EHGIQHPTTN SVMMVVYSKQ MRTESSTLIR TAEHSKYVAQ DRALSEPVAR
RHKRNHRAHK RVSEAAGDSA IPALTQVEGE QKTLCKKVDM WVDFDQIGWS EWIIYPKRYN
AYRCEGDCPT PVDESFAPTN HAYMQSLLKL HQPDRVPCPS CVPTRLAPLS MLYYENGKMV
MRHHEGMVAG ACGCH
//
