ID A0A2D0T2Q0_ICTPU Unreviewed; 2414 AA.
AC A0A2D0T2Q0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
GN Name=notch1a {ECO:0000313|RefSeq:XP_017348865.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017348865.1};
RN [1] {ECO:0000313|RefSeq:XP_017348865.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017348865.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_017348865.1; XM_017493376.3.
DR STRING; 7998.ENSIPUP00000008304; -.
DR Ensembl; ENSIPUT00000008666; ENSIPUP00000008304; ENSIPUG00000005717.
DR GeneID; 108279276; -.
DR KEGG; ipu:108279276; -.
DR CTD; 30718; -.
DR OMA; TCHEQRD; -.
DR OrthoDB; 5473534at2759; -.
DR Proteomes; UP000221080; Chromosome 18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 36.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 21.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 17.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 35.
DR PROSITE; PS01186; EGF_2; 28.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2414
FT /note="Neurogenic locus notch homolog protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013175183"
FT TRANSMEM 1730..1752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..56
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 57..97
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 100..137
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 138..174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 176..214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 216..253
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..291
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 293..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 333..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 410..448
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 488..524
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 526..562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 564..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 601..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 639..674
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 676..712
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 714..749
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 751..787
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 789..825
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 827..865
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 867..903
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 905..941
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 943..979
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 981..1017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1019..1055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1057..1093
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1143..1179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1181..1217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1219..1263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1265..1303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1305..1344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1346..1379
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1382..1420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1448..1488
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1489..1520
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1527..1567
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1914..1946
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1981..2013
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2014..2046
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2047..2079
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1776..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2143..2165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2375..2405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 430
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 433
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 450
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 451
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 453
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 467
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 468
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 488
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 489
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 505
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 506
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 24..34
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 46..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 87..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 127..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 164..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 204..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 243..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 359..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 379..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 398..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 414..427
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 421..436
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 438..447
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 454..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 459..474
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 492..503
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 497..512
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 514..523
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 552..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 568..578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 589..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 627..636
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 643..653
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 664..673
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 702..711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 718..728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 739..748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 777..786
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 815..824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 836..853
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 855..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 893..902
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 931..940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 969..978
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1007..1016
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1045..1054
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1083..1092
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1131..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1169..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1207..1216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1253..1262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1274..1291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1293..1302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1334..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1369..1378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1391..1408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1410..1419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2414 AA; 258703 MW; 656E89450766FE77 CRC64;
MNRFLLMSLF LGTAPVCEGK GLRCSEPCQN GGACELTAGG KPGCSCPVDY AGAQCQFPNP
CSPSPCRNGG VCRPRTQGND VEFACDCTLG FSGPLCLTPV NHACMSSPCR NGGSCSLLTL
STYSCRCPPG WTGKTCQQAD PCASNPCANG GRCSAFDSHF ICTCPPSFHG PTCRQDVNEC
ATTPSPCQNS GACINEVGSY RCHCPPEYAG THCERPFQPC QPSPCANGGT CTQTSDTGYA
CTCLPGFTGQ DCEHNIDDCV QHACENGGRC MDGVNTYNCH CDKHWTGQYC TEDVDECELS
PNACQNGGTC HNTVGGFHCV CVNGWTGDDC SENIDDCASA ACYHGATCHD RVASFYCECP
HGRTGLLCHL DDACISNPCQ KGSNCDTNPV NGMAICTCPP GYTGSACNQD IDECSLGANP
CEHGGRCLNT KGSFQCKCLQ GYEGPRCEMD VNECKSNPCQ NDATCLDQIG GFHCICMPGY
EGVFCQINTD DCASQPCLNN GKCIDKINSF HCECPKGFSG SLCRVDVDEC ASTPCQNGAK
CTDGPNKYAC ECKEGFTGSM CEIDINECAS NPCHYGVCKD GVASFACACR PGYAGRLCEI
NINECLSQPC RNGGTCLDRE NSYTCSCPKG TTGRNCEINV DDCKRNPCDF GKCIDKINGY
ECLCEPGYTG ATCNADIDDC VPNPCRNGGT CVDGVNSFTC LCPDGFHDSV CLSQRDECAS
NPCIHGNCQH QANAYVCVCE PGWTGRNCDL NVNECLSSPC VNGGTCRDMT NGYICSCKAG
FTGPNCQTNI NECASNPCLN QGTCIDDVAG YKCNCLLPYT GELCESVLAP CSTRPCKNRG
VCRESEDYQS FSCACPIGWQ GQTCEVDINE CVKSPCRNGG ACVNSMGGFQ CRCNPGFTGD
LCETDVDDCT PNPCGNGGVC VDRVNGFTCV CVAGFRGERC TEDIDECVSA PCRNGGNCTD
CVNSYTCSCP AGFSGINCEI NTPDCTESSC FNGGTCVDGI NSFSCVCLPG FTGSYCQHDV
NECDSGPCLN GGTCQDGYGT YKCTCPHGYT GTSCQSLVRW CDSAPCKNGG SCWQQGSSFT
CQCASGWTGI YCDVPSVSCE VAAQQQGVSV AALCRNGGQC VDAGSTHLCR CQAGYMGSYC
QEQVDECVPN PCHNGATCTD YLGGYTCECV AGFHGVNCSK EINECASQPC QNGGTCIDLV
NTYKCSCPRG TQGVHCEIDV DDCSPDVDSE TGEPRCFNGG RCVDRVGGYG CVCPPGYVGE
RCEGDVNECL SDPCDPNGSY NCVQLVNSYR CECRTGYTGQ RCDTVFDGCK DKPCKNGGTC
AVASNTKHGY ICKCPPGFSG SSCEYDSSSC GPLRCRHGAS CVPGPRCLCL PGYTGRECQT
RLDTPCASNP CYNGGTCQTS AEAPFFHCLC PSHFNGLFCH ILDYSFNGGR GLDITPPPAE
SEEAEPRCEV PQCEQRGGDG VCDAACNSHA CGWDGGDCSL NFDDPWHECS AALQCWRYFN
DGKCDMQCHS AGCLYDGFDC HQLEGQCNPL YDQYCKDHYS DGHCDQGCNS AECGWDGLDC
AEDVPQRLAS GILVLVVHLP PGELLHNASS FLRQLSALLR TNVALKRHAT TGEPLVYPYY
GTEHELSKHT RTAHEWNTNP GHLLQRTARS LSALLKPRPR RELDTMEIKG SIVYLEIDNR
QCYQQSEECF QSATDVAAFL GALASSGNLN VPYIIEAVTS ENEAPGRGEM YPMFLALLVL
AVLVLAAVGV VLSRKRKREH GQLWFPEGFK VTETKKKRRE PVGEDSVGLK PLKNSDSSLM
DEQLSEWAEE DHCKRFRFDE HTTTDIGIQP DPRQWTQQHL DAADLRLTSI APTPPRADTD
TDCVDVNVLG PDGLTPLMIA SCSGEVGEEE EGEEGVIANF LWHGADPHQR TERAGETALH
LAARYARSDA AKRLLESGAD ANAQDHAGRT PLHAAVASDA QGVFQILIRN RATDLDARMN
DGTTPLILAT RLAVEGMVEE LINCHADANA IDDSGKSALH WAAAVNNVEA AVVLLKNGAN
KDLQDNKEET PLFLAAREGS YETAKRLLDH LANRDITDHL DQLPRDIANE RMHHDIVRLL
EEYNLVQTPP TLTHSPPICS PEAFLGIRTS PGGANNANNA KKPRKPGGKE GGKEMKMKKK
KNGDTNILSP MESDVSSPPT MTSPFQQSPP ITHHLQGLAD SQMGGAHLGM AKPFDSAPPR
LSHLGVANNG GGAPTGPCDW LARAQQQQQG AFSAIMPTMH HGANLPQVMG YPTMQSSHLG
APAHLLSNHL HQNHLQHQNS NSANHGLSHH FLGDITSVAE LQSNSIQTLL PQETQRLPST
QFLTPPSQHS YSTPMDNTPN HQPQVPDHPF LTPSPGSPDQ WSSCSPHSNL SDWSEGISSP
PTSIHMSHIP EAFK
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