ID A0A2D0T3B7_ICTPU Unreviewed; 800 AA.
AC A0A2D0T3B7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protein kinase C-binding protein NELL2 isoform X3 {ECO:0000313|RefSeq:XP_017349306.1};
GN Name=nell2b {ECO:0000313|RefSeq:XP_017349306.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017349306.1};
RN [1] {ECO:0000313|RefSeq:XP_017349306.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017349306.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_017349306.1; XM_017493817.3.
DR AlphaFoldDB; A0A2D0T3B7; -.
DR Ensembl; ENSIPUT00000010093; ENSIPUP00000009668; ENSIPUG00000006599.
DR GeneID; 108279511; -.
DR CTD; 336082; -.
DR OrthoDB; 5487at2759; -.
DR Proteomes; UP000221080; Chromosome 19.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Kinase {ECO:0000313|RefSeq:XP_017349306.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|RefSeq:XP_017349306.1}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..800
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013379468"
FT DOMAIN 53..224
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 268..327
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 438..479
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..551
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 600..635
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 636..691
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 696..755
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 523..533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 541..550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 800 AA; 88916 MW; 6058619F7B4BDEEB CRC64;
MALFQFCFAL CVLSVCAVEL DPALRVDILK ELNVGESFTG VSPVQGFHID TTAFLFKGTR
RSVRASAGVA ERILQKLRGR VEISLLLTLK QDKFNSGVLL SIHHGEQRYL ELESNGQHSE
IRLHYRMAEQ QNRTEIFPYN LADARWHRVA LTLSTTQLVL YVDCSRIYER IVETPSMDIP
AGTTVWLGQR NNVHGFFKGV MQEVQLVFMP QGYISQCPDL NRTCPTCNDF HSLVQKIMEL
QDILAKTSGK LARAEERMKT LDGCYCERTC SLNGEIYRDE DVWIDGCKNC TCLNGSVECE
SIFCPAPQCP PDTAPAYIPG ACCKECQPLC IFRGRVYVEG ERKSMRDSTG NCLLYECRDR
KMRRVESIAC PELSCPESEQ ITLTDRCCKV CQGHDFCADG YSSSCVENSE CVNLEAGACC
SCKDGYRAVR DDSAYCHDID ECAEGKHYCR ENTVCVNTPG SFMCVCNKGY IRIDDYSCTE
HNECISGLHS CDENALCFNT VGGHSCTCKP GYLGNGTVCR AQCDGLCHNG GSCVAPDTCV
CLQGFTGKRC ETDIDECLNG FVECDSRATC VNLPGWYHCE CRDGYHDNGM FLSNGESCED
IDECEAGRHS CANDTVCFNM DGGYDCRCPH GKNCTGDCFH DGKVKHNRQI WVLEEDRCAV
CSCQSGLVMC RRMVCDCENP TVDVSCCPEC DPRLSSQCVL YSGLLTYNSG DTWVEKCQQC
QCIHGEVDCW PMPCAPLTDC EFVAVPDGEC CPRCISDPCQ ADTLFNDVTK TCVDEHGATR
LSGSTWNKHA TECSICQCKS
//
