ID   A0A2D0T3E0_ICTPU        Unreviewed;       765 AA.
AC   A0A2D0T3E0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Rho GTPase-activating protein 17b isoform X3 {ECO:0000313|RefSeq:XP_017349115.1};
GN   Name=arhgap17b {ECO:0000313|RefSeq:XP_017349115.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017349115.1};
RN   [1] {ECO:0000313|RefSeq:XP_017349115.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017349115.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017349115.1; XM_017493626.3.
DR   AlphaFoldDB; A0A2D0T3E0; -.
DR   GeneID; 108279379; -.
DR   CTD; 100141341; -.
DR   OrthoDB; 7959at2759; -.
DR   Proteomes; UP000221080; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd04386; RhoGAP_nadrin; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR   PANTHER; PTHR14130:SF3; RHO GTPASE-ACTIVATING PROTEIN 17; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          14..246
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          255..445
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          483..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          169..196
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        497..514
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..585
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..617
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..713
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..749
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   765 AA;  83630 MW;  ABAE9F195989585C CRC64;
     MKKQFNRMKQ LANQTVGRAE KTEVLSDDLL QIERRMEIVR LVSHNTHKKL VSCLQGHVGA
     DVEKRHKKLP LMGLSQAMVD GAGQLGEDCM IGKMIEVCGE AESKLALEQS QHEVQLEKEV
     LDPLNQLAEV DIPNIMKQRK QLAKLVLDYD SARARYLQAT KAILTATNNQ AMTAKADSCK
     EEMDEAHNKV EICKDQLAAD MYNFSSKEGE YARYYVMLLE AQAEYHRRSL ASIESVLPAI
     RSQEETWMEK PAFGTALEEH LKRSNREIAL PIEACVMMLL ETGMKEEGLF RIAAGASKLK
     KLKAALDCST SQLEEFYSDP HAVAGALKSY LRELPEPLMT FQHYDDWIQA SNVSDPDKRL
     QALWVTCDNL PKANKANLKY LVKFLAKLAQ ESEVNKMTPS NIAIVLGPNL LWAKTEGTLA
     EMAAATSVHV VAIIEPIIQH ADWFFPEDLE FNVSGMFVMP TGPVHQPGYP ATPEPEYATI
     ERRRPGSQGA LEIETPRKDS PTSKHPEHTP RRTGTLNRKQ QQQQHTSPAF QPPLPPVEAG
     GVPASEAPSQ SAVGGSEAGA IMAQNQQPIN QQQSAEENSS VVREPASTPP PLRNGPGGPS
     GTPGQLTVVT PASTSKGPSP HLVRRGTKKQ APAPPKVAPN SSSSATTPLK ATPFSAQAQN
     QNPATSPAQP VTLPRRQSSS QMPIHAPSHP PPQPPQNSTD PEPSPPHSPT LPDMPPHDST
     HSASLYRPRP VPRPRPRPSV PPPPQPPSES SNGVCNSASK IITDV
//