ID A0A2D0T3R9_ICTPU Unreviewed; 445 AA.
AC A0A2D0T3R9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Iroquois-class homeodomain protein IRX-2a isoform X1 {ECO:0000313|RefSeq:XP_017349466.1, ECO:0000313|RefSeq:XP_017349554.1};
GN Name=irx2a {ECO:0000313|RefSeq:XP_017349466.1,
GN ECO:0000313|RefSeq:XP_017349554.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017349466.1};
RN [1] {ECO:0000313|RefSeq:XP_017349466.1, ECO:0000313|RefSeq:XP_017349554.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017349466.1,
RC ECO:0000313|RefSeq:XP_017349554.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR RefSeq; XP_017349466.1; XM_017493977.3.
DR RefSeq; XP_017349554.1; XM_017494065.3.
DR STRING; 7998.ENSIPUP00000000093; -.
DR Ensembl; ENSIPUT00000000120; ENSIPUP00000000093; ENSIPUG00000000094.
DR GeneID; 108279631; -.
DR KEGG; ipu:108279631; -.
DR CTD; 394032; -.
DR OMA; TLGQGCQ; -.
DR OrthoDB; 2915644at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF15; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 120..183
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 122..184
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 47684 MW; 00B5F87A4034F61A CRC64;
MSYPQGYLYQ PGPGSLALYP LRSEELELAA RCSSSSSSSS SSSSSSSSTG SAFTPYPASA
AFTASAAGGF ASALSYHTDP ATGFPSYMAS PYDPPPSAMA APLGFPPYGS AGFPPSPYQL
NDPAYRKNAT RDATSTLKAW LNEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL
KKENKVTWGA RAKSEDEDEE EGVRAERKDE EDEEDDKHAD NGDASAEDEG ISLHVDSLTD
HSAESDGEKV LCRIDDFSCK PAPEAKEKRS EIDLASGHGG HGGLSPKPMT SSPLTGVEAP
LLDAHRDKNK TCADVQSQNT KPKLWSLAEI ATSDPKQPLQ SQNCPSGGGI WTSGQSSVAP
SASILARPIY YTSPFYGNYA NYGNFGQGIL RYGSLHKHAP ETPMLKANHA NHVQTEQHFR
ALSAEAKKAD SGDVCTLGPQ SYLSS
//
