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Database: UniProt
Entry: A0A2D0T599_ICTPU
LinkDB: A0A2D0T599_ICTPU
Original site: A0A2D0T599_ICTPU 
ID   A0A2D0T599_ICTPU        Unreviewed;       746 AA.
AC   A0A2D0T599;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=slc26a3.2 {ECO:0000313|RefSeq:XP_017349995.1,
GN   ECO:0000313|RefSeq:XP_017349996.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017349996.1};
RN   [1] {ECO:0000313|RefSeq:XP_017349995.1, ECO:0000313|RefSeq:XP_017349996.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017349995.1,
RC   ECO:0000313|RefSeq:XP_017349996.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   RefSeq; XP_017349995.1; XM_017494506.3.
DR   RefSeq; XP_017349996.1; XM_017494507.3.
DR   STRING; 7998.ENSIPUP00000022565; -.
DR   Ensembl; ENSIPUT00000023588; ENSIPUP00000022617; ENSIPUG00000015298.
DR   GeneID; 108279896; -.
DR   KEGG; ipu:108279896; -.
DR   CTD; 563896; -.
DR   OMA; ALYWIPK; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000221080; Chromosome 19.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        68..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        97..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        161..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        236..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        272..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        361..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        456..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          511..704
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   746 AA;  82363 MW;  910CC34BEC7403B3 CRC64;
     MAQYVVSRPL YTEDAFTDDY EKVWRQHKTM LDHVKQYFTC NSNRAKNAAL SLLPIIGWMK
     LYNVREWILG DIVSGVSTGL VAVLQGLAYS LLASLPAWYG LYAAFFPVII YFFFGTSRHI
     SVGAFPVLSL MVGSVVTRLV PDEGPVANIT GFEGLTMDQQ RAMVSASLTF LIGIFQLAMG
     LLQVGFIVIY LSDTLVSGFT TAAAVHILVS QLKFIFGLKV PGFSGPLALV TILQKTFVQI
     TSTNIHDLVT SIVVMFVVFI VKELNDRYKK KLPVPIPIEV IMTIIACGVS YAFNFQANYG
     VDVVGKIPDG FEAPLAPNLQ IFQETAVDAF PMCIVGFAVA FAVAKVYAVK HDYVIDGNQE
     LIAFGASNIF GGAFKSLAAS TALSRSAVQE STGGKTQVAG LLSAIIVLIV TLAIGFLLEP
     LPKSVLGAVV IVNLKGMLMQ VSEVPYLWRK DRPDCIVWIV TCVGSILLGL DIGLAVGLGI
     EMIAVVFRTQ FPHCCVLANI SGTDIYRNRK DYVNIYEPEG VKIFRIPSPI FFANIDFFRG
     KLLDAVGFNP LRVLRKRNKA LRKIKKLIKK GELRVTSKGL QATCSLPIEE SEDESNMEDL
     DQPIDFSDLP VQVNWRAELP ANISVPPVDI HSLVLDFSAV SFLDISALKG LKTALKEFIR
     IDIEIYIVAC DPYIIEKLKS CKFFDDEITT SIFFLTLHDA MLHILYLHPP LSISEKVNIN
     SCDKLNNGMN SLRNREKTGK EPETRF
//
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