ID A0A2D0T599_ICTPU Unreviewed; 746 AA.
AC A0A2D0T599;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN Name=slc26a3.2 {ECO:0000313|RefSeq:XP_017349995.1,
GN ECO:0000313|RefSeq:XP_017349996.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017349996.1};
RN [1] {ECO:0000313|RefSeq:XP_017349995.1, ECO:0000313|RefSeq:XP_017349996.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017349995.1,
RC ECO:0000313|RefSeq:XP_017349996.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_017349995.1; XM_017494506.3.
DR RefSeq; XP_017349996.1; XM_017494507.3.
DR STRING; 7998.ENSIPUP00000022565; -.
DR Ensembl; ENSIPUT00000023588; ENSIPUP00000022617; ENSIPUG00000015298.
DR GeneID; 108279896; -.
DR KEGG; ipu:108279896; -.
DR CTD; 563896; -.
DR OMA; ALYWIPK; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000221080; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 68..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 97..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 361..378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 456..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 511..704
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 746 AA; 82363 MW; 910CC34BEC7403B3 CRC64;
MAQYVVSRPL YTEDAFTDDY EKVWRQHKTM LDHVKQYFTC NSNRAKNAAL SLLPIIGWMK
LYNVREWILG DIVSGVSTGL VAVLQGLAYS LLASLPAWYG LYAAFFPVII YFFFGTSRHI
SVGAFPVLSL MVGSVVTRLV PDEGPVANIT GFEGLTMDQQ RAMVSASLTF LIGIFQLAMG
LLQVGFIVIY LSDTLVSGFT TAAAVHILVS QLKFIFGLKV PGFSGPLALV TILQKTFVQI
TSTNIHDLVT SIVVMFVVFI VKELNDRYKK KLPVPIPIEV IMTIIACGVS YAFNFQANYG
VDVVGKIPDG FEAPLAPNLQ IFQETAVDAF PMCIVGFAVA FAVAKVYAVK HDYVIDGNQE
LIAFGASNIF GGAFKSLAAS TALSRSAVQE STGGKTQVAG LLSAIIVLIV TLAIGFLLEP
LPKSVLGAVV IVNLKGMLMQ VSEVPYLWRK DRPDCIVWIV TCVGSILLGL DIGLAVGLGI
EMIAVVFRTQ FPHCCVLANI SGTDIYRNRK DYVNIYEPEG VKIFRIPSPI FFANIDFFRG
KLLDAVGFNP LRVLRKRNKA LRKIKKLIKK GELRVTSKGL QATCSLPIEE SEDESNMEDL
DQPIDFSDLP VQVNWRAELP ANISVPPVDI HSLVLDFSAV SFLDISALKG LKTALKEFIR
IDIEIYIVAC DPYIIEKLKS CKFFDDEITT SIFFLTLHDA MLHILYLHPP LSISEKVNIN
SCDKLNNGMN SLRNREKTGK EPETRF
//