ID A0A2D0T5J5_ICTPU Unreviewed; 423 AA.
AC A0A2D0T5J5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Transcription factor EC {ECO:0000256|ARBA:ARBA00019430};
GN Name=tfec {ECO:0000313|RefSeq:XP_017350096.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017350096.1};
RN [1] {ECO:0000313|RefSeq:XP_017350096.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017350096.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR RefSeq; XP_017350096.1; XM_017494607.3.
DR AlphaFoldDB; A0A2D0T5J5; -.
DR Ensembl; ENSIPUT00000022449; ENSIPUP00000021517; ENSIPUG00000014576.
DR GeneID; 108279937; -.
DR CTD; 22797; -.
DR OMA; YPEENSI; -.
DR OrthoDB; 3061893at2759; -.
DR Proteomes; UP000221080; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18925; bHLHzip_TFEC; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF1; TRANSCRIPTION FACTOR EC; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 183..236
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 288..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..270
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 395..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 46964 MW; 53FAC75AC3A3B898 CRC64;
MSHRCVVKVI SLTEVQLLPV QNHLETSKYH LHQAQAQQVK QYLTLGTKLP GQAHPHPGQA
LGTMPVMRNG HMTPVSDNST PGSPVTLFTL ANSHDTEFPV DEVIDDLIGF ESGFNDGSLE
CMEPSIIMQN NVALNSGMLE VYGGDQGMTA SHGGLTPPSC PPKLSVKMEV TEHDTRVLAK
ERQKKDNHNL IERRRRYNIN YRIKELGTLI PKSNDPDMRW NKGTILKASV EYIKWLQKEQ
QHARELESRQ KKLEQANRRL LLRIQELEIQ ARAHGLPSNL GAAEISSHLL KQQQQQQQQQ
QQALPAPAVT PGAQTSLYPQ DELNGPEYLQ RNSLSVLHAG NEGNSSSSGE HADATSTTFS
DPLSHFTDFF SATLKEEQRL DELLMEEALS PFGTDPLLSA TSPNASKGSS RRSSFSTDDN
DDL
//
