ID   A0A2D0T639_ICTPU        Unreviewed;       708 AA.
AC   A0A2D0T639;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=EF-hand calcium-binding domain-containing protein 4B isoform X2 {ECO:0000313|RefSeq:XP_017350367.1};
GN   Name=cracr2ab {ECO:0000313|RefSeq:XP_017350367.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017350367.1};
RN   [1] {ECO:0000313|RefSeq:XP_017350367.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017350367.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017350367.1; XM_017494878.3.
DR   AlphaFoldDB; A0A2D0T639; -.
DR   GeneID; 108280118; -.
DR   CTD; 564347; -.
DR   OrthoDB; 3685636at2759; -.
DR   Proteomes; UP000221080; Chromosome 19.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd00154; Rab; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR   PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          61..96
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..221
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          250..355
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        13..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..390
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  81356 MW;  BE46A16E5C533356 CRC64;
     MSEFLHHQNM KVVYKSSDNE DRQPESEMME GVERRGSGLV PASLLEKIDE FFQRLNKELP
     LSADELENVF DSLDLDRNGR LTLEEFSSGF SKFLQGRRMS QVEDQLSGLS QDFPEALYQN
     EPQDYEEERH FSTLMESLGA SNIFEDPSEV HTLWTQLRKD EPHLLYNFED FLARVTSQIR
     VAQQEKREME SALRKKAATH NGEIQQLYEE MEQQIKNEKD RLSHKDFRSQ DLQQQLSSKE
     QELEWLFLKQ RRLEQQCQEL HSEHQESQVE NIKLKMTNQE LSRELEHTCH ELSLAQKQLA
     KLQEQGLRLQ QEKNMEVYRI TERLQREKQN LVNQLDLLRE MNKHLRDEKD SLKCSNLLKK
     ATLEQDPASN LTVHSDRKQA TEREVGTEVT QHPNRKTSSC SSSPHSASRD DGMMRAAKHT
     ASAGRDSVSE NPDPNAVDPP PFHRVISIEE DHLPHLLEGE CYPVFHQMNE EEGALIDLQM
     SPMYFSSMSA NMAFVTRGQL VGKETLQKGP VESSITTPQR LYKVILVGNS NVGKTALLHR
     FCDGHFHTDT TATVGIDFSV RTLNLGDSHV ALQLWDTAGQ ERFRSITKQF FRKADGVVVT
     YDITLCDSFK SVRSWLVSIQ ETVGGPVPIM LLGNKSDRES MRQVATGEGE RLAKEAGLLF
     YECSAYTGSN VLEAMVHLAR VLKEQEDRVW ERTVQLVDPP VKKKTCCM
//