ID A0A2D0T8X2_ICTPU Unreviewed; 2178 AA.
AC A0A2D0T8X2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X6 {ECO:0000313|RefSeq:XP_017351323.1};
GN Name=dock10 {ECO:0000313|RefSeq:XP_017351323.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017351323.1};
RN [1] {ECO:0000313|RefSeq:XP_017351323.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017351323.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_017351323.1; XM_017495834.3.
DR GeneID; 108280633; -.
DR CTD; 55619; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000221080; Chromosome 20.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 172..281
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 674..851
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1705..2165
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 138..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2178 AA; 248664 MW; 499067D4E0D1BA8D CRC64;
MSFRSKITFR KKMKTRRARA DFSRISCQEK PKLIDPLDYE AVITELELEL KEDPLQDLLL
FPDHDFTVST LPQERRTQQS TVPEGAEEQA ESLLVRQACQ YYNSQLHMVE YKYQEYAGDY
RMLPRKLHKA QKLPTHSFEI DHEDVDKDED TTSLSSSKGG GGGGGSGGGG TGVFKSGWLY
KGNFNSTVNN SITVRSFKRR YFQLTQLTDN SYIMNFYKDE KISKEPKGCI FLDSCTGVVQ
NNRLRKHAFE LKMNEVTYFV LAAESEQDME DWINTLNRIL QISPPEVTAL DRKSLDLTDT
RHDVFDLSSN NGCLTENEET TENGINPELA KYITETEETV RAARREERLN LFSLDPDTPV
LRSPRGDCGE PSHIRPFEEK LGKRLMIYCR SLNLTLQGCV NEAETEPVTN IEPFFVTLAL
LDMRENRKVS ADFHVDLNHE IVRKMLSGLG NPGSQGTPGG HGGVQENGLK SPTEKRSGDC
QLSQELEDWL CFPKQAIFSI TNPHTDIVMV ARIEKVLMGN ITSGTEPYIK NTDNSKTVQK
MLKSNKQFCS KLGKYRMPFA WSVRSVFKDN QGMVDRESRF SPLFKQESNK ISTEDLLKLI
TEYRRAEKTS KLQTIPGSLE ISVDCVPMEH PNAVTSSYVP VKPFDDCSLH APTVEVEEFL
QDSAKFAQPY RVYKNHIYVY PKHLKYDSQK SFAKARNIAV YVEFRNSDEE HAKPLKCIYG
KPGGPVFTTA ACSTVLHHSQ NPDFYDEVKI ELPTQLHEKH HLLFSFFHVT CDINAKTSSK
KKEALETPVG YAWLPLLKDG RLTSQEFNVP VSCTLPTGYL LIKESSSSKN GSDVKWVDGG
KPIFKVSTLV LSTVYTQDPH LNRFFQQCQK RETDFSQPPT SNFLNCLKGL LSMERNHVII
RFLPILFNQL FKVLTQNDSD DVTTTTTRVL VHILSKCHEE NLDRYLHSYI KFVFKTEAHG
FRTVHEELAK GMNSDLKSNE QSAVKNILKF SWFFLEIIAK SMAQHLVDSE KLKVPRSQRF
PGTFQSHLET LIMTMSDHIY WKSKDLPDET RSASQAIAAF VKRCFNLMDR GFTFKLISNY
INMIANSDNK MLCEFKFEFL REVCNHEHYI PLSLPIPSAQ IPDKASSETQ SAQVDMPEYN
LTGEFCRKHF LTGLLLRELG LALQDEQDIR HLALASLKNL MAKHSLDSRY ALKEKQARIA
SLYLPLYGLI LDNMPRFFLR DLFPIYLTSS DQHIPTKIQP RGRIYKEGSK DDVSVGGGGG
ALACQSGHST RHGNSVDVAL SKEVLNSITV FSSLAVSTAN NTDSRGSLIS IESNPSNSDR
NSEKMDGCEK FTRPQSLIGF GSRFDKLDQA ETRSLLMCFL HIMKTISEDV MVAYWHRAIQ
QEISDFFNIL ELCLQHFRFL GKRHIARKLA AAVKLAQATQ NTGTLKGSNA STQSSGLLPQ
WMLSGQDGHR HARSHTMPIL RGKNALTNPK LLQMMETVDG NSAENDNFNP TDIEANLSTE
VSLTVLDVLG LFVQHHKKQL QQDEGQNYLM KKVFDTYLLF FQINQSTTTL RHVFAALRLF
IQKFPCVFFQ GKADLCGCLC YEILKCCNHR SSSTQTEAAA LLYFLMRKNF EFTKGKCIVR
SHLQVIKAVS QLIADAGIGG SRFQQSLAII NNFANGDAPL KNTTFPADVK DLTKRIRTVL
MATSQMKEHE KDPEMLVDLQ YSLANSYAST PELRRTWLES MAKIHVRNGD LSEAAMCYIH
ISALIAESLK RRGYWKPEKA RISTMGTEEA NVINCCPLLT PQEGETSFSM GWPAFMNITP
NVQEEGAMKE DTGTQDTPYT EDTLVDQLEL CVDYLWKSER HELIADINKP VIAVYEKRRD
FKRLSELYYD IHRSYLKVNE VVNSEKRLFG RYYRVAFYGQ GFFEEEESKE FIYKEPKLTG
LSEISQRLLK LYSDKFGADN VKMIQDSNKV NPKDLDPRFA YIQVTYVVPY FDEKEQQEKK
TDFERNHNIN RFVFETPFTL SGKKHGDVEE QCKRRTILTT SSMFPYLKKR IQVVKQQSTE
MNPIEVAIDE MSRKVSELNQ LCKMDEVDMI RLQLKLQGSV SVKVNAGPMA YARAFLEEKN
AKKYPDNQVK LLKEIFRQFA DACGQALDVN ERLIKEDQLE YQEEMRAHYK DMLNELSAIM
NEQILHGRQS VTERPNAF
//