ID A0A2D0TA04_ICTPU Unreviewed; 475 AA.
AC A0A2D0TA04;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=RAB guanine nucleotide exchange factor (GEF) 1, like {ECO:0000313|RefSeq:XP_017351711.1};
GN Name=rabgef1l {ECO:0000313|RefSeq:XP_017351711.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017351711.1};
RN [1] {ECO:0000313|RefSeq:XP_017351711.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017351711.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017351711.1; XM_017496222.3.
DR AlphaFoldDB; A0A2D0TA04; -.
DR STRING; 7998.ENSIPUP00000007223; -.
DR Ensembl; ENSIPUT00000007537; ENSIPUP00000007223; ENSIPUG00000004981.
DR GeneID; 108280803; -.
DR KEGG; ipu:108280803; -.
DR CTD; 393915; -.
DR OMA; GHYQANV; -.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000221080; Chromosome 20.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF107; RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 1-RELATED; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00167; VPS9; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 13..47
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 236..379
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 65..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52845 MW; 23B3CD9B5C739AC5 CRC64;
MSSKTERRGI YVDQAALLCK KGCGFFGNSA WGGFCSKCWR EVNQKDRAKQ IEEDHALAER
LQREEEATYA GSNAGAQSGN SSTQLSKPEE KRNSQKPLTV PAGKKFFSTL AKTTLGRDVN
VPSQPAPTTS ISQQPVVEPD QATRQFIDFL KTVQKPGRDI FKQCHSFCHS VAYKKDLGAE
DLSESVQDFY QNLSDRLHTV YKGSPERIEV IMDEVEKYIT LQLYEQAFCP ESADDEVKDL
AIQKRIRALH WVTVQMLCAP LKEEIPAVSD SLDKAITDVI EMDSKRVPRD KLGYVTRCSK
HIFSAIKRSK REAASADDFL PALIYVVLKA NPPRLQSNIQ YITRFCNPRR LMSGEDGYYF
TNLCCAIAFI EKLDAQSLNL SPEEFELYMS DQASPDRPQA PGISFSSSSS SRSGPRADRP
ENDLIDWGDG VEASVQDVLD GLHLDSCTPS TSAIDSDNVD SEGLPPPLQP QVFAG
//
