ID A0A2D0TAF1_ICTPU Unreviewed; 309 AA.
AC A0A2D0TAF1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Vesicle-associated membrane protein-associated protein A {ECO:0000256|ARBA:ARBA00018309};
GN Name=vapa {ECO:0000313|RefSeq:XP_017351837.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017351837.1};
RN [1] {ECO:0000313|RefSeq:XP_017351837.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017351837.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004521}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004521}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17)
CC family. {ECO:0000256|ARBA:ARBA00008932}.
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DR RefSeq; XP_017351837.1; XM_017496348.3.
DR AlphaFoldDB; A0A2D0TAF1; -.
DR STRING; 7998.ENSIPUP00000036472; -.
DR Ensembl; ENSIPUT00000037901; ENSIPUP00000036472; ENSIPUG00000024426.
DR GeneID; 100528164; -.
DR CTD; 9218; -.
DR OrthoDB; 122649at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR InterPro; IPR016763; VAP.
DR PANTHER; PTHR10809; VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR10809:SF155; VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR PIRSF; PIRSF019693; VAMP-associated; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..124
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
FT REGION 181..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 231..258
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 188..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 34173 MW; A04DC4F7D7A61FF2 CRC64;
MSKLEQILIL DPPSDLKFKG PFTDVVTTNL KLRNPSDKKV CFKVKTTAPR RYCVRPNSGS
IDPGSSVIIS VMLQPFDYDP NEKSKHKFMV QTIYAPSNVT DLEAVWKDAK PEDLMDSKLR
CVFELPSENE KLSGMCGPVA GLRTPRMQQC VGSCSASTPG DYCTPAGSRN LTDEQEVFDF
PSVRPGQRSG WDRQSQNDVD PTKAAPMLNS SKADNTSAAK PSSLALEDPE MRKVVEECKR
LQSEVSKLGD ENRQLKDEGL RMRKAQRSEN VVSNTAGMVR KETSSKSLPS LLVVIAAIFI
GFFLGKFVL
//