ID A0A2D0TAI4_ICTPU Unreviewed; 1934 AA.
AC A0A2D0TAI4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Myosin-7 {ECO:0000256|ARBA:ARBA00039815};
DE AltName: Full=Myosin heavy chain 7 {ECO:0000256|ARBA:ARBA00041438};
DE AltName: Full=Myosin heavy chain slow isoform {ECO:0000256|ARBA:ARBA00043207};
DE AltName: Full=Myosin heavy chain, cardiac muscle beta isoform {ECO:0000256|ARBA:ARBA00041905};
GN Name=LOC108280896 {ECO:0000313|RefSeq:XP_017351886.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017351886.1};
RN [1] {ECO:0000313|RefSeq:XP_017351886.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017351886.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity
CC essential for muscle contraction. Forms regular bipolar thick filaments
CC that, together with actin thin filaments, constitute the fundamental
CC contractile unit of skeletal and cardiac muscle.
CC {ECO:0000256|ARBA:ARBA00037090}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_017351886.1; XM_017496397.3.
DR STRING; 7998.ENSIPUP00000013304; -.
DR Ensembl; ENSIPUT00000013861; ENSIPUP00000013304; ENSIPUG00000009014.
DR GeneID; 108280896; -.
DR KEGG; ipu:108280896; -.
DR OMA; CDEYQRT; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000221080; Chromosome 20.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF1; MYOSIN-7; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 29..78
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 82..776
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 653..675
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1905..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 175..182
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1934 AA; 223419 MW; A5D81C08A4A4B641 CRC64;
MGDAEFGVAG PYLRKSEKER LEAQTRIFDM KKECFVPDPV EEFVKATITS REGDKVTVET
ESGKTLTFKD SQILQQNPPK FDKIEDMAML TFLHEPAVLY NLKERYAAWM IYTYSGLFCV
TVNPYKWLPV YNQEVVIAYR GKKRSEAPPH IFSISDNAYQ YMLSDRENQS LLITGESGAG
KTVNTKRVIQ YFASIAASGT KKDLPGQNKG TLEDQIIQAN PALEAFGNAK TIRNDNSSRF
GKFIRIHFDT RGKLASADIE TYLLEKSRVT FQLKAERDYH IFYQILSNKK PEILEMLLVT
PNPYDYAFIS QGETTVPSID DAEELMATDN AFDVLGFTQE EKNSIYKLTG AIMHFGNMKY
KQKQREEQAE ADGTEDADKA AYLMGLNSSD LIKGLCHPRV KVGNEWVTKG QNVQQVNYAI
GALSKALYEK MFHWMVVRIN QSLETKQPRQ YFIGVLDIAG FEIFELNTFE QLCINFTNEK
LQQFFNHHMF VLEQEEYKKE GIEWTFIDFG MDLQACIDLI EKPMGIMSIL EEECMFPKAT
DATFKAKLYD NHLGKSSNFQ KPRIIKGKPE AHFALVHYAG TVDYNIINWL IKNKDPLNET
VVGLYQKSSL KLLALLFANY AGVDTALADS GKKEKKKKGS SFQTVSALHR ENLNKLMTNL
RSTHPHFVRC IIPNESKTPG AMENPLVMHQ LRCNGVLEGI RICRKGFPNR ILYGDFKQRY
RILNPSAIPE GQFIDSKKGA EKLLASLDVD IQQYKFGHTK VFFKAGLLGQ LEEMRDERLS
KILTGIQARS RGLLSRFEYQ KMVERRDALL VIQWNVRAFM SVKNWPWMKL YFKIKPLLRS
AEAEKEMANM KEEFLKLKEA YAKSEARRKE LEEKMVSLLQ EKNDLQLQVQ AEQDNLCDAE
ERCEGLIKNK IQMEAKVKDL NERLEDEEEM NAELTAKKRK LEDECSELKK DIDDLELTLA
KVEKEKHATE NKVKNLTEEM AALDEIIAKL TKEKKALQEA HQQTLDDLQS EEDKVNTLTK
IKVKLEQQVD DLEGSLEQEK KVRMDLERAK RKLEGDLKLA QESIMDLEND KQQLEERLKK
KDFEISQLNS KIEDEQVIIA QLQKKIKELQ ARVEELEEEL EAERAARAKV EKQRADLARE
LEEISERLEE AGGATVAQIE MNKKREAEFQ KLRRDLEEAT LHHEATAATL RKKQADSVAE
LGEQIDNLQR IKQKLEKEKS ELKLELDDVV SSMEQIVKSK TNLEKMSRTL EDQLNEFRNK
CEESQRSLND FVTQKAKLQS ENDELSRQVE EKDSLIFQLT RGKQSYSQQL DDLKRQLEEE
VKAKNALAHA VQSARHDSDL LREQYEEEQE AKTELQRSLT KANAEVAQWR TKYETDAIQR
TEELEEAKKK LAQRLQDAEE AVEAVNAKCS SLEKTKHRLQ NEIEDLMVDM ERSNAAAAAL
DKKQRNFDKV LAEWKQKYEE SQCELESSQK EARSLSTELF KLKNSYEESL DHLETLKREN
KILQEEISDL TEQLGEGGKT IHELEKARKQ LEQEKTDIQS ALEEAEGSLE HEEGKILRSQ
LELNQIKSEN ERKLAEKDEE MEQTKRNLQR TIDTLQSSLE AETRSRNEAF RVKKKMEGDL
NEMEIQLSQA NRQAAEAQKQ LKIIQSNLKD CQIQLDDFIH ANDDLKENTA IVERRNVLLQ
AEIEELRSLL EQTERGRKLA EQELLDVSER VQLLHSQNTS LLNQKKKQEA DISQLQCEVE
DSIQECRNAE EKAKKAITDA AMMAEELKKE QDTSAHLERM KKNMEQTIKD LQQRLNEAEQ
IAMKGGKKQV QKLEARVREL ESELEAEQKR SSETVKGIRK YERRIKELSY QSEEDRKNIG
RLQDLVDKLQ LKVKAYKRAA EDAEEQANVH LGKFRKLQHE LDEAEERADV AESQVNKLRA
KSREPGSKKG FDEE
//
