ID A0A2D1SPU7_9BACL Unreviewed; 602 AA.
AC A0A2D1SPU7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Oligoendopeptidase F {ECO:0000256|RuleBase:RU368091};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU368091};
GN Name=pepF {ECO:0000313|EMBL:ATP39124.1};
GN ORFNames=CSE16_03270 {ECO:0000313|EMBL:ATP39124.1};
OS Solibacillus sp. R5-41.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Solibacillus.
OX NCBI_TaxID=2048654 {ECO:0000313|EMBL:ATP39124.1, ECO:0000313|Proteomes:UP000222866};
RN [1] {ECO:0000313|EMBL:ATP39124.1, ECO:0000313|Proteomes:UP000222866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R5-41 {ECO:0000313|EMBL:ATP39124.1,
RC ECO:0000313|Proteomes:UP000222866};
RA Guo Y., Chen Z., Wang H.;
RT "Complete genome sequence of Solibacillus sp. R5-41.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has oligopeptidase activity and degrades a variety of small
CC bioactive peptides. {ECO:0000256|RuleBase:RU368091}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU368091};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU368091};
CC -!- SIMILARITY: Belongs to the peptidase M3B family.
CC {ECO:0000256|RuleBase:RU368091}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP024123; ATP39124.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D1SPU7; -.
DR KEGG; sob:CSE16_03270; -.
DR OrthoDB; 9766487at2; -.
DR Proteomes; UP000222866; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09608; M3B_PepF; 1.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR Gene3D; 1.10.287.830; putative peptidase helix hairpin domain like; 1.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR004438; Peptidase_M3B.
DR NCBIfam; TIGR00181; pepF; 1.
DR PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368091};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU368091};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU368091};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU368091};
KW Reference proteome {ECO:0000313|Proteomes:UP000222866};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU368091}.
FT DOMAIN 115..184
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 205..584
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 602 AA; 68935 MW; 6BDBFD9914FF65ED CRC64;
MSKKVLTRNE VPEHLTWDLT SIFATDDAWE VELKEVEKLS EQAADFKGKV AESAESLYNT
LQFSNQLMER LHKLYVYSHL KHDQDTTNSK YQDLDGRIRS SAAKMGATWS FVTPEILALD
EATLDSFVAS YEPLELYKQS LKELNLGRPH VLSAEKEELL AQLSEVSSAS GTTFSALNNA
DLEFPIIKNE DGEDVQLTHG NYITMLESDN REVREAAFKA MYQVYGQFKN TFATTLSGNV
KAHNADAKIR NYESARHAAL SNNFIPEKVY DQLISTVHDF LPVLHRYVSL RKKVLGVDEL
HMYDLFTPLV KEVKMEVTYD EAKKMMVDSF APLGKEYQDS VQTGLDSRWV DVLENKGKRS
GAYSSGTFGT NPYVLMNWQN NVNNLYTLAH EFGHSMHSFY SRANQPYPYA DYSIFVAEVA
STCNEELLFD YLMKTLDDDK QKIYLLNQWL DGFRGTVFRQ TMFAEFEHMI HEMDRKGEAL
TAEKLTEIYY NLNKQYFGED ISVDEEIGLE WARIPHFYYN YYVYQYATGQ SAATALSKQI
LEEGQPAVDR YINNFLKAGC SDFPIEVLKA AGVDMESPEP IALACKVFEE KLEELEKLLL
NN
//
