ID A0A2D1SVQ8_9BACL Unreviewed; 627 AA.
AC A0A2D1SVQ8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=CSE16_14565 {ECO:0000313|EMBL:ATP41178.1};
OS Solibacillus sp. R5-41.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Solibacillus.
OX NCBI_TaxID=2048654 {ECO:0000313|EMBL:ATP41178.1, ECO:0000313|Proteomes:UP000222866};
RN [1] {ECO:0000313|EMBL:ATP41178.1, ECO:0000313|Proteomes:UP000222866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R5-41 {ECO:0000313|EMBL:ATP41178.1,
RC ECO:0000313|Proteomes:UP000222866};
RA Guo Y., Chen Z., Wang H.;
RT "Complete genome sequence of Solibacillus sp. R5-41.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP024123; ATP41178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D1SVQ8; -.
DR KEGG; sob:CSE16_14565; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000222866; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:ATP41178.1};
KW Hydrolase {ECO:0000313|EMBL:ATP41178.1};
KW Nuclease {ECO:0000313|EMBL:ATP41178.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000222866}.
FT DOMAIN 207..325
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 440..583
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 627 AA; 71250 MW; F66140CF515AA331 CRC64;
MGKIHIMDEW LSNKIAAGEV VERPSSVVKE LVENAIDAHS TSIEIFLEEA GLSSIQVVDN
GSGMDEEDAL KSFSRHATSK IEKEQDLFRI RTLGFRGEAL ASIASVSKFT LRTSDGEGGV
HLYLEGGHLK EHQPTSLRKG TDITVAQLFF NTPARLKYLK TIQTELGHTI DFVNRIALGY
PTVAIKLVHN GQTLLQTNGR GQVQQVLAAI YGTHNAKKMI AFEGTNQDYK IHGFASLPEV
TRASKNYMSL FVNGRWVKHY VIQKAITDAY HTFLPIERFP IVLLYVEGDP QLTDVNVHPA
KHQVRLSKEP ELLKLIEDTL RQTIRDVIRV PLAEKIEKPV RVPGEQMNLW NPSKTSAATL
DETKMDELVE RLTNEQQSVV KEPFAPAPYY EQVERPKSSE TVGSPYMTQV KPIPNEPFQH
EIIEEQLAET PKQPFPQLEI VGQIHGTYIV AQMEDGFYLI DQHAAQERIK YEYFKEKVGE
VNANERQALL MPLTFHYAAD EALILKESMS ALEEVGVFLE EFGHASFVIR EYPTWFPKGE
EQEVIEELIE QVLKTRKTDI KKLREAAAIM MSCKKSIKAN HFLDKEQMER LLTDLRAAEN
PFTCPHGRPV LVHFTTYEVE KMFKRVM
//
