ID A0A2D2MC57_9PSED Unreviewed; 1247 AA.
AC A0A2D2MC57;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Bifunctional diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:ATR85065.1};
GN ORFNames=CS390_22375 {ECO:0000313|EMBL:ATR85065.1};
OS Pseudomonas sp. HLS-6.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=2049589 {ECO:0000313|EMBL:ATR85065.1, ECO:0000313|Proteomes:UP000230810};
RN [1] {ECO:0000313|EMBL:ATR85065.1, ECO:0000313|Proteomes:UP000230810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLS-6 {ECO:0000313|EMBL:ATR85065.1,
RC ECO:0000313|Proteomes:UP000230810};
RA Hu Y., Zhang T., Lei D., Yao S., Lin K., Chen X., Cui C.;
RT "Complete genome of Pseudomonas sp. HSL-6, a multiple-antibiotic-resistant
RT bacteria isolated from drinking water source in East China.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP024478; ATR85065.1; -; Genomic_DNA.
DR RefSeq; WP_065759046.1; NZ_CP024478.1.
DR AlphaFoldDB; A0A2D2MC57; -.
DR Proteomes; UP000230810; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 4.
DR CDD; cd01007; PBP2_BvgS_HisK_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 4.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 3.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 4.
DR SMART; SM00091; PAS; 4.
DR SMART; SM00062; PBPb; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 4.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 4.
DR PROSITE; PS50112; PAS; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230810};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1247
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013770203"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..366
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 384..434
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 435..482
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 508..558
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 633..683
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 680..726
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 753..805
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 837..970
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 979..1233
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 542..569
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1247 AA; 139454 MW; F92857A24BE23E3A CRC64;
MLRLPAILLL LQLLWSATAG ALTLTDEEQA WLSAHPQLRL GVDASWPPFE YRDQEGRYQG
LAADYITLLE DRLGVAFKPI EPISWTAVLE EARNGKLDLL PGIMSTPERQ SYLSFTRPYL
DFPIVILAHQ GGAQPHDLKD LYGLKVAVVE NYAPHELLRT HHPDLNLVAL PNVSSTLQAL
ATDQVDAVVG DLASSIWSLR QQKLEGLYVS GETPYRYQLA MAVPREEKIL VAILDKVLAD
MSPGEISNIQ ERWVGKVLDR RTGWYDLLMY GLPGILVLLT ILAVVIWSNR RLSSEISRRI
ALEQELRSSE YHYRGLIESL SAIAWEADTE DFTYSYVSPH AENLLGYPLS DWLKPGFWNS
ILHPDDALWA QAYCDSETAA GRDHSLDYRV ITADGRSLWV RDIVSLIEHG HKPVMRGLMI
DISEAKNTEL ALRLSEQKFA SVFQQCPDIL VIARLSDGCL LEVNEAFEEQ LGLSPAHVIG
KTATELNIWG IEGIGPKLLR RLQAGKVRNL EMLFKRRNGQ VFTGLTSVEA FQLDSTPALV
VAVRDISQLK EAQDQLQTSE EKFAKAFHAS PDGLLLSRQR DGRLIEVNEG FCRLTGYDLS
VTLDRTSIDL GIWVDLNERK RLLELLERDG FVRDYTCHIR RSDGQIRLCE LSARPLPIAG
EECMLTIARD ITERHLMQEK LQLAATVFEN TAEGVLITDT EQRISAVNRA FSEITGYSEF
EALGQTPRLL ASGQHDSAFY AAMWHQLTAE GHWQGEIQNR RKNGEVYPGW LTISAVRNSG
REITHFVAVF ADISSIKHAQ AKLDYQAHHD PLTGLPNRTL FESRLQAALS CTQTSKAQGA
VLFLDLDRFK HINDSLGHPV GDLLLKGIAH RLKEQVRDID TVARLGGDEF IILLPGLHQP
SDAEHIAAKL LNCFSAPFQA GEHEFFTSAS IGTSLYPQDG SDVASLIRNA DAAMYRSKAK
GRNRVESYTR DLTAQASARV ALEHELRRAI ERDELSLYYQ PKFSLKTQSL IGAEALIRWS
NPTFGDVPPE HFIALAEENG MILQLGDWVL EHACRQMQQW KETYLAFGPL SINLAGAQLR
QPSLVKRIEQ LLNTYHLSAG DLQLEITENF IMSQAEEALA ILHQLKRLGV QLAIDDFGTG
YSSLSYLKRL PLDILKIDQS FIRGLPDDPH DAAIARAIIA LGRSMQLTII AEGVENLAQQ
RFLAAEGCEQ IQGYIVSLPL PPEEFAATFL RIAVSDLSDG TAWKPSL
//
