ID   A0A2D3UWP7_9PEZI        Unreviewed;       303 AA.
AC   A0A2D3UWP7;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Probable aldehyde reductase {ECO:0000313|EMBL:CZT16667.1};
GN   ORFNames=RCC_02502 {ECO:0000313|EMBL:CZT16667.1};
OS   Ramularia collo-cygni.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Ramularia.
OX   NCBI_TaxID=112498 {ECO:0000313|EMBL:CZT16667.1, ECO:0000313|Proteomes:UP000225277};
RN   [1] {ECO:0000313|EMBL:CZT16667.1, ECO:0000313|Proteomes:UP000225277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=URUG2 {ECO:0000313|EMBL:CZT16667.1,
RC   ECO:0000313|Proteomes:UP000225277};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FJUY01000003; CZT16667.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2D3UWP7; -.
DR   STRING; 112498.A0A2D3UWP7; -.
DR   OrthoDB; 5305445at2759; -.
DR   Proteomes; UP000225277; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF504; GLYCEROL 2-DEHYDROGENASE (NADP(+))-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000225277}.
FT   DOMAIN          15..279
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         107
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            76
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   303 AA;  33365 MW;  1CCBB610B5D6B20D CRC64;
     MATFTLNTGA KIPAVGLGTW QSPPGEVKAA VAHALKSGYR HIDAAFVYGN EKEVGEGLKE
     AFDSGIKREE VFVTSKLWCT YHREPEKCLD EGLKRLGLEY VDLYLMHWPA PMNPDGNDPL
     APKKPDGSRD MDTEWSHVQT WKELEKLLKT GKTKAIGVSN YSVKYLEELL PQATVVPAAN
     QVENHPSLPQ HELVDYCKSK GILVEAYSPL GSTGSPLFKM EGVQEVAKKH GVGAGTVLIS
     YQVSRGNVVL PKSVTPSRIE ENLKVVKLDA GDIKALDEIH KVHGVTRYVF PPFGLDFGFP
     DKQ
//