ID   A0A2D5Z922_9BACT        Unreviewed;       807 AA.
AC   A0A2D5Z922;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=CMJ18_15330 {ECO:0000313|EMBL:MAE65639.1};
OS   Phycisphaeraceae bacterium.
OC   Bacteria; Planctomycetota; Phycisphaerae; Phycisphaerales;
OC   Phycisphaeraceae.
OX   NCBI_TaxID=2026777 {ECO:0000313|EMBL:MAE65639.1, ECO:0000313|Proteomes:UP000222953};
RN   [1] {ECO:0000313|Proteomes:UP000222953}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Tully B.J., Graham E.D., Heidelberg J.F.;
RT   "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT   Global Oceans.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MAE65639.1}.
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DR   EMBL; NYZC01000239; MAE65639.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2D5Z922; -.
DR   Proteomes; UP000222953; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.590; -; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          103..302
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          399..737
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
SQ   SEQUENCE   807 AA;  89774 MW;  E891BF416AC14EDB CRC64;
     MSRSARHPDA IGFLLDVFHR RKGDRFAVFG IGRLESGETF GFVDDREPPG FWIRASELDR
     AQHLAPAEGI AIDPVHAVDP NQWTTLDGET VTFAGGERLA DTKAFATRLE EHGVRTYEAD
     ISPSRRFLIN RGIRGGVRVH GPWQPGHDVD RVYLDPDLAP EDWAPALAVL ALDIETDARA
     ERVYAVSLVG TGPGPRHVTE EVHLVGRPGD DDPDCATCHP DETALLDAVA DRIRRIDPDV
     ITGWNVIDFD LRVLQERAEA IGSPMKLGRA GDTSWYRQGD AWGGSRVTIR GRQVVDAMRL
     VRVIPRRFED YRLGTVARDI LGRDKTLESD EDTSMPEVIM RAYREDRPAF CAYCLEDSRL
     VRDILEATGL VAMTLRRSML TGLALENAWG SIAAFDFLYL DRLHRQRIVA PTLGVDRKDA
     GGAPGGLVMP ARAGLHPHVF VFDFMSLYPS IISTFNIDPL AHVRAESLPS SDVITAPNGA
     TFAREQGILP AMLEEFFAQR STAKGAGDEL ASFTYKIVMN SFYGVLASGS CRFASPRLAG
     AITGFGHELL RWAAAALDDL GAAVLYGDTD SLFVDARLPD DIALDDALEH GRRLCDRMNR
     MIADHLREKY GVSSRLELEF EKYYRRLFLP VSRADETRAR AKGYAGLRMA PGVEEVEIIG
     MEAARHDWTN LAHDLQRRLL DLLFHDAPPG DIEQCVARCV EDVRAGRRDA DLVYRKRLRK
     KVDDYTRTSP PHVKAARLLS KPPSVIHYVM TTDGPQPVGH VSAPLDYGHY VDKQIRPIVH
     AIAQVCDIDE QVGGMKQLML FDVRSRI
//