ID A0A2D6FL56_9BACT Unreviewed; 570 AA.
AC A0A2D6FL56;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=CMI54_04450 {ECO:0000313|EMBL:MAF43407.1};
OS Parcubacteria group bacterium.
OC Bacteria.
OX NCBI_TaxID=2026774 {ECO:0000313|EMBL:MAF43407.1, ECO:0000313|Proteomes:UP000221304};
RN [1] {ECO:0000313|Proteomes:UP000221304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Graham E.D., Heidelberg J.F.;
RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT Global Oceans.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MAF43407.1}.
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DR EMBL; NYZL01000045; MAF43407.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D6FL56; -.
DR Proteomes; UP000221304; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00141; NT_POLXc; 1.
DR CDD; cd07436; PHP_PolX; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.150.110; DNA polymerase beta, N-terminal domain-like; 1.
DR Gene3D; 3.30.210.10; DNA polymerase, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR002054; DNA-dir_DNA_pol_X.
DR InterPro; IPR010996; DNA_pol_b-like_N.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR037160; DNA_Pol_thumb_sf.
DR InterPro; IPR002008; DNA_pol_X_beta-like.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR029398; PolB_thumb.
DR InterPro; IPR022311; PolX-like.
DR InterPro; IPR047967; PolX_PHP.
DR PANTHER; PTHR36928; PHOSPHATASE YCDX-RELATED; 1.
DR PANTHER; PTHR36928:SF1; PHOSPHATASE YCDX-RELATED; 1.
DR Pfam; PF14791; DNA_pol_B_thumb; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF14716; HHH_8; 1.
DR Pfam; PF02811; PHP; 1.
DR PIRSF; PIRSF005047; UCP005047_YshC; 1.
DR PRINTS; PR00870; DNAPOLXBETA.
DR SMART; SM00481; POLIIIAc; 1.
DR SMART; SM00483; POLXc; 1.
DR SUPFAM; SSF47802; DNA polymerase beta, N-terminal domain-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..315
FT /note="DNA-directed DNA polymerase X"
FT /evidence="ECO:0000259|SMART:SM00483"
FT DOMAIN 339..418
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 570 AA; 65214 MW; 18D0BBF576029745 CRC64;
MKNQEIAKIL YKIADYLDIE EVSFRPKAYR RAALALETLK KDVREIYKQG RREALEGIPG
IGKSIAEIIE EYLNTGKVKY YEQLKKKLPI NFEEITRIEG MGLRKAKFLY QKLGIRNLKD
LEKAAKAHKI APLFGFGEKT EKNILEGIKF LKRSKGRFLL GEILPTVNEV QKKLKKLKGV
ETVSLAGSIR RMKETIGDAD FLVISKNPQK VMDFFVHLPG VIKIWGKGTT KSSVRIKEGF
DMDIRVVPKR SYGSALQYFT GSLEHNIITR KIAMAKGLKL SEYGLFRGSK MIASKTEKEV
YKKLGMDWVP PEIRENQGEI GLALKGRLPK LIGYNDIKGD LHTHSDWNGG LNSIEELAEA
AQKMGYEYIG IADHTKFLKI EHGLNEKQLA QRNKTIDKLN KKIKNFKILK GAETNILNDG
SIDIKDESLA KLDFVIAGVH STMKMEKEKM TERIIKAMKN PHVDIISHPT GRILKRREEY
QFDFDKILRA AKETGTILEI NSFPNRLDLN DKNIRLAKEA GVKMIINTDS HHKDHFPFME
FGIAQARRGW AEKRDIINCW PLKNLLSFFK
//
