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Database: UniProt
Entry: A0A2D6FNM3_9BACT
LinkDB: A0A2D6FNM3_9BACT
Original site: A0A2D6FNM3_9BACT 
ID   A0A2D6FNM3_9BACT        Unreviewed;       461 AA.
AC   A0A2D6FNM3;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CMI54_08900 {ECO:0000313|EMBL:MAF44260.1};
OS   Parcubacteria group bacterium.
OC   Bacteria; unclassified Parcubacteria group.
OX   NCBI_TaxID=2026774 {ECO:0000313|EMBL:MAF44260.1};
RN   [1] {ECO:0000313|EMBL:MAF44260.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ARS57 {ECO:0000313|EMBL:MAF44260.1};
RX   PubMed=29337314; DOI=.1038/sdata.2017.203;
RA   Tully B.J., Graham E.D., Heidelberg J.F.;
RT   "The reconstruction of 2,631 draft metagenome-assembled genomes from
RT   the global oceans.";
RL   Sci. Data 5:170203-170203(2018).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:MAF44260.1}.
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DR   EMBL; NYZL01000089; MAF44260.1; -; Genomic_DNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      157    289       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      368    437       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     165    172       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   461 AA;  53069 MW;  AF533EEDC19316EE CRC64;
     MNSRRYLSIK HSLMNEQELW QAVLAQVQFH ISPANFATWF KNTSILSKKE GEVMVSVPNN
     FSREWLENKY NKLILKTVRN LEKGVKEIKY ITTSQSLKIK QPQVWTQETD QLEFQELKVN
     KDTNLNPRYK FENFVVGPFN ELPYAAASAI TKSPGSVYNP LFIYGGVGLG KTHLIQAIGN
     EIVKNFSERK IKYISSEKFT SGIITAIKER AISGLKSAYQ EIDVLIIDDI QFIAGKEKTQ
     EEFFHIFNAL YEKNKQVILS SDRPPKAIPA LEERLRSRFE GGMIADISLP DLETRIAILK
     TKSQEKKINI SDQILEYIAS HIQRNIRELE GALNRLIAYQ KLNNQPPDLN TIKGLLKSII
     NNPVKVTNHK KIIQAVAEFY DLKEEDLLCK SRKKEIVKPR QIAMYLLRTE LKGSYPFIGR
     KFRGKDHTTA IYACNKVIAE LEKDENLTEE VILIKQRIYS L
//
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