ID A0A2D8PEP9_9RHOB Unreviewed; 698 AA.
AC A0A2D8PEP9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:MAM63935.1};
GN ORFNames=CMH11_20815 {ECO:0000313|EMBL:MAM63935.1};
OS Maritimibacter sp.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Maritimibacter.
OX NCBI_TaxID=2003363 {ECO:0000313|EMBL:MAM63935.1, ECO:0000313|Proteomes:UP000224593};
RN [1] {ECO:0000313|Proteomes:UP000224593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Graham E.D., Heidelberg J.F.;
RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT Global Oceans.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MAM63935.1}.
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DR EMBL; NZNT01000030; MAM63935.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D8PEP9; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000224593; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 296..472
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 477..570
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 604..688
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 698 AA; 74767 MW; 0A788B80AAE70089 CRC64;
MSETRAINDV ISLETVGKVG LVCIDNPPVN ASSQAVRQGL LDAVAAANDD DAIEVIAIYA
AGRTFVAGAD IKEFGKPPLQ PSLPDTINAI EASAKPVISA PHGTALGGGL EICMGTHARV
GVKGLRVGLP EINLGLLPGA GGTQRGPRLM GMEHTLDMAL SGRMVTGEEA LGWGLIDRLE
DGAPRDVALS AAEAVLDGTL PTRRTGELPV EVDDAALDAA RKMVEKKMPN LASAPKCIEA
VERATGSVED GMKFERECFM SLLKHPSSEG MRHAFFAERA VSKIPEANAT PREIRKIGVI
GGGTMGSGIA TAALTSGFAV RLIEVAQDGL DRGVGAITKN LDGAVKRGKM AADKRDAAMA
RLEPSLNMED LADVDLVIEA VFEDMGVKKD IFGQLDKICK AGAVLASNTS YLDINEIASA
TSRPEDVIGL HFFSPANIMR LLEVVVADKT APEVVATGFA LAKKMKKIGV RAGVCDGFIG
NRILAYYGKT AGYLVEDGAS PQQVDQALEN FGFAMGPFKV GDLAGLDIGW ANRKRMAPNR
PNAERYVRIH DKICEEGMFG RKTGQGFYIY DDNGIRPNPR TLEIIDEERA AKGITPKRFT
DEEIVERYMT AMISEAARVV EDGIALRPID VDAVFLFGYG FPRFRGGPLH YADTIGAKEL
VARIERFAED DSYYWNVPDI LRRMAADGTT FADLNKES
//
