ID A0A2E8EES0_9ARCH Unreviewed; 300 AA.
AC A0A2E8EES0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=methylenetetrahydrofolate reductase (NADH) {ECO:0000256|ARBA:ARBA00034529};
DE EC=1.5.1.54 {ECO:0000256|ARBA:ARBA00034529};
GN Name=metF {ECO:0000313|EMBL:MBQ04157.1};
GN ORFNames=CL673_05540 {ECO:0000313|EMBL:MBQ04157.1};
OS Candidatus Bathyarchaeota archaeon.
OC Archaea; Candidatus Bathyarchaeota.
OX NCBI_TaxID=2026714 {ECO:0000313|EMBL:MBQ04157.1, ECO:0000313|Proteomes:UP000230510};
RN [1] {ECO:0000313|Proteomes:UP000230510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Graham E.D., Heidelberg J.F.;
RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT Global Oceans.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway. {ECO:0000256|ARBA:ARBA00034478}.
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBQ04157.1}.
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DR EMBL; PBSW01000038; MBQ04157.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2E8EES0; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000230510; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR InterPro; IPR004620; MTHF_reductase_bac.
DR NCBIfam; TIGR00676; fadh2; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 300 AA; 33780 MW; 9F038E2B931E745D CRC64;
MKIRDFIAKE RTILSFEFFP PKTKEDEDHL FETIRKLESF TPNFVSVTYG AGGGTQKNTR
HVVKRIKEET SLTPMAHLTC IGQHQEELTG ILSDFTATGI ENILALRGDP PEETTGRAPK
DRPCYAKDLV RLAASFNAFS IRVAVYPEGH FESPNLGVDM VYTKEKIDAG ADFAITQMFF
DNRYFYQFME RADQAGIRVP VIPGIMPITN IEKVKRFSQM CGATLPAHLV ERMEAAASPS
EARKIGIDFA IKQCENLWEN GVRYFHFYTM NSSKAVAEIL HGLDLGQGSN RHFPTAEESI
//
