ID A0A2E9CCN4_9ARCH Unreviewed; 911 AA.
AC A0A2E9CCN4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=CME83_00040 {ECO:0000313|EMBL:MBS84941.1};
OS Candidatus Heimdallarchaeota archaeon.
OC Archaea; Asgard group; Candidatus Heimdallarchaeota.
OX NCBI_TaxID=2026747 {ECO:0000313|EMBL:MBS84941.1, ECO:0000313|Proteomes:UP000228988};
RN [1] {ECO:0000313|Proteomes:UP000228988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Graham E.D., Heidelberg J.F.;
RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT Global Oceans.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBS84941.1}.
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DR EMBL; PBWW01000001; MBS84941.1; -; Genomic_DNA.
DR Proteomes; UP000228988; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322:SF20; DNA POLYMERASE 1; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 103..356
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 471..840
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 911 AA; 103906 MW; 3F2FA33D7FD0C2EA CRC64;
MINVSLEDFF ETTPPPKKPP KEKVVINEKK ELNTFNPPIT PQFPDYFTPK PIKNEKNIDN
LFLLDVQYNG KLNLAQLIFY HEETQSLYYW NDNTNHKPYL ITMLSEESIN SIDQVVKSKD
YLKIEKTSKY LPIEEQDMEV IKVYGDNPLA IGGSGTSFRN FLNPSFEADI RYHFNYVADK
QLTPATYYKI ENGELKQIDQ NIGSIKNELE IEFKDENEEE KEMLNEYMPL LFQKMPDVTR
CAYDIEIGSD KNRLPNITTT PDPIISIALV DNLGRKICWV LKRPEVDQPF NQIEDKSVNV
LLYDSELDLL VDFFHIVDQX PIALSFNGDN FDNPYLINXA KKLGLDYNXX PIKQKGRSDT
TFNNSIHVDL YLFXRQASIR LXAFGGKXER SSLQELSSSL XGEGKIDHPE VWINEMDLKT
LVKYNVKDAE LTLQLTQFDN NVVLDLIFIL MRICKMPIFD FIRTAVSGWL KMWLIYEHRK
RNFLIPRKED ILSAKGAAPT SDAIIEGKKF QGAIVLDPKP GVWWNVHVLD FASLYPSIIK
TRNLSYETIL CNHEDCSDNV VPEVGHNICT KRVGLFAIVL GFVRDTRVKW FKPRSSDSNL
PELERRNNDV IQSSLKVLIN AGYGVFGSDT FDFYCPPVAE STTAYARDAI KSTKNYVENT
LGVDVLYGDT DSVFLYGPTE EQISKLLDWG LENIGVELGT DYVFRYVVFS DRKKNYFGIT
TNGNIIVKGL MGKKSNTPQI IRKTFTNVLN ILKNVNNPDE FPIAREQIVN TLKQMVNKLE
TGNFTPEDIS VRITLSKKLS DYSTWTQTVQ AAAQLLGDDN FNEEITVGST IEYIKLKTPK
RIVVPNHKDL AFPSGESQKV SVKPVLLIKE GEKLDGKPVI EAAESTFSQI LSSIGSSWND
VMGVMSLDDF F
//
