ID A0A2E9CFV6_9ARCH Unreviewed; 606 AA.
AC A0A2E9CFV6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Excinuclease ABC subunit UvrC {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=CME83_06140 {ECO:0000313|EMBL:MBS86115.1};
OS Candidatus Heimdallarchaeota archaeon.
OC Archaea; Asgard group; Candidatus Heimdallarchaeota.
OX NCBI_TaxID=2026747 {ECO:0000313|EMBL:MBS86115.1, ECO:0000313|Proteomes:UP000228988};
RN [1] {ECO:0000313|Proteomes:UP000228988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Graham E.D., Heidelberg J.F.;
RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the
RT Global Oceans.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBS86115.1}.
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DR EMBL; PBWW01000063; MBS86115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2E9CFV6; -.
DR Proteomes; UP000228988; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881}.
FT DOMAIN 5..83
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 197..232
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 289..476
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:MBS86115.1"
SQ SEQUENCE 606 AA; 70050 MW; DE21C624A4022A5B CRC64;
KVLPSSPGVY VIFDEKEIPI YVGKASNLSN RVRSHFAKST DFSKSRVIRE RGYKIEVHVT
STENEALLLE YNMIQELQPS LNSQYTDGKT YPYLEVTTGE QWPRFLKTRE KNNPNSIYLG
PYSDVGSMQR SLRYVLKLFP VADCHKEIHL GDADDWAKTC IRRRTKQCMR PCELEIDDNE
YRENVDQVIN FMEGKLPDIL NDVEKKMREA SAIEEFEKAA KYRDVMKSIN RTMQKQSVFV
DDVDNMYVVV QEENKFEIGL SLQKIIDGRI IRREVAVMPK NSEGSFQDFV IQYLIAMLNL
NVTNNVKSED KIKKIILVTD NFKEIKDVLI TFDYDIVQKE NDAEEQIIKM AKNHIKSHLQ
RRLLIKKDKE LPTKRVEDLR EMLGFDLPPL IIDTFDVSTL MGRNNVGSCV RFVNGKPLKK
GYRKFKITSV DQQDDFASMY EIVFRRYKDV NDGFDKKGLP IPDLIVIDGG REQLNRGLLA
LGDNNLKIPI IGLAKREEEI YFSDIEEPMN EDNNRGGMLL LRACRDEAHR FAVTYQRSLR
QKEGLVSILD EIDGIGPKRR KLLIRKYKTV NAIAKESSET LSENFGLSKK LSSKVIDACR
KFTISN
//
